Edaravone CAS# 89-25-8 依达拉奉
Edaravone, also known as Radicut and MCI-186, is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke. Edaravone exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Edaravone provides the desirable features of NOS: it increases eNOS (beneficial NOS for rescuing ischemic stroke) and decreases nNOS and iNOS (detrimental NOS).
📌 参考资料/链接：
MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark. Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. Bioorganic & Medicinal Chemistry Letters. Department of Chemistry. Dalhousie University. Halifax, Can. B3H 4R2. Volume 26. Issue 1. Pages 100-104. 2016.
MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark. Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. Bioorganic & Medicinal Chemistry Letters. Department of Chemistry. Dalhousie University. Halifax, Can. B3H 4R2. Volume 26. Issue 1. Pages 100-104. 2016.
📄 详细内容
CAS No. 89-25-8 依达拉奉Edaravone synthetic routes
MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark. Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. Bioorganic & Medicinal Chemistry Letters. Department of Chemistry. Dalhousie University. Halifax, Can. B3H 4R2. Volume 26. Issue 1. Pages 100-104. 2016.
产品链接: CAS No. 89-25-8 ››
MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark. Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. Bioorganic & Medicinal Chemistry Letters. Department of Chemistry. Dalhousie University. Halifax, Can. B3H 4R2. Volume 26. Issue 1. Pages 100-104. 2016.
产品链接: CAS No. 89-25-8 ››