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临床前CDMO研发化合物筛选
Thiamine HCl (Vitamin B1)
中文名称:盐酸硫胺
CAS号:67-03-8
分子式: C12H17N4OS.HCl 分子量: 337.27
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Congenital Heart Disease; Thiamine Deficiency; Patent Ductus Arteriosus; Ventricular Septal Defect; Atrial Septal Defect
研究机构: Universitas Sumatera Utara
研发日期: May 1 2024
研发阶段: Early Phase 1
Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes.
Crenolanib (CP-868596)
中文名称:[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺
CAS号:670220-88-9
分子式: C26H29N5O2 分子量: 443.54
产品形式: free base
研发状态: Completed
研发用途: Advanced Solid Tumors
研究机构: Arog Pharmaceuticals Inc.
研发日期: Dec-05
研发阶段: Phase 1
Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Calcium gluconate monohydrate
中文名称:葡萄糖酸钙
CAS号:66905-23-5
分子式: C12H22O14.Ca.H2O 分子量: 448.39
产品形式: monohydrate
研发状态: Not yet recruiting
研发用途: Arthritis of Carpometacarpal Joint of Left Thumb; Arthritis of Carpometacarpal Joint of Right Thumb
研究机构: Brent DeGeorge; University of Virginia
研发日期: June 1 2024
研发阶段: Phase 1
Calcium gluconate (Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen) is element or mineral necessary for normal nerve, muscle, and cardiac function. Calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally.
Halobetasol Propionate
中文名称:卤倍他索丙酸酯
CAS号:66852-54-8
分子式: C25H31ClF2O5 分子量: 484.96
产品形式: free base
研发状态: Recruiting
研发用途: Psoriasis
研究机构: Bausch Health Americas Inc.
研发日期: March 24 2021
研发阶段: Phase 4
Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.
Linagliptin (BI-1356)
中文名称: 利格列汀
CAS号:668270-12-0
分子式: C25H28N8O2 分子量: 472.54
产品形式: free base
研发状态: Terminated
研发用途: Diabetes Mellitus Type 2
研究机构: Boehringer Ingelheim
研发日期: March 4 2020
研发阶段: --
Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.
BIO
中文名称:GSK 3抑制剂IX
CAS号:667463-62-9
分子式: C16H10BrN3O2 分子量: 356.17
产品形式: free base
研发状态: Not yet recruiting
研发用途: Healthy Volunteer
研究机构: International Bio service
研发日期: September 23 2024
研发阶段: Phase 1
BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
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