专利号:US-9732272-B2 优先权日:2010-12-28 标 题:Synthesis of highly fluorescent GSH-CDTE nanoparticles (quantum dots) 发明人:PEREZ DONOSO JOSE MANUEL; MONRAS CHARLES JUAN PABLO; OSORIO-ROMAN IGOR ORLANDO; VASQUEZ GUZMAN CLAUDIO CHRISITAN 权利人:UNIV SANTIAGO CHILE 摘要:The invention relates to a method for the synthesis of glutathione-capped cadmium-telluride (GSH-CdTe) quantum dots in an aqueous medium, including the steps of: a) preparing a precursor solution of cadmium in a citrate buffer; b) adding glutathione (GSH) to the preceding mixture via strong agitation; c) adding a telluride (potassium or sodium telluride) oxyanion as a telluride donor to the preceding mixture; d) allowing the preceding mixture to react; and e) stopping the reaction by incubation at low temperature.
专利号:US-12391691-B2 优先权日:2018-11-16 标题:Synthesis of key intermediate of KRAS G12C inhibitor compound 发明人:PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY 权利人:AMGEN INC 摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as
专利号:US-2025206736-A1 优先权日:2019-11-14 标题 :Synthesis of kras g12c inhibitor compound 发明人:CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN 权利人:AMGEN INC 摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
专利号:US-5344775-A 优先权日:1991-11-15 标题 :Synthesis of taxanes in culture using pseudocalluscells 发明人:SMITH RICHARD J 权利人:ESCAGENETICS CORP 摘要:A method of synthesis of taxanes from pseudocallus of Taxus species, particularly T. baccata , and methods for pseudocallus production are described. Pseudocallus of the invention can be distinguished from callus tissue and cell suspensions by (1) its unique morphology which is characterized by an amorphous aggregation of cells lacking both differentiated tissues and clearly defined meristematic zones; by (2) very poor intercellular adhesion resulting in marked tissue friability; and by (3) relatively high initial rate of mass doubling. Production of taxanes is achieved by culturing the pseudocallus on support culture medium.
专利号:US-2017268027-A1 优先权日:2014-12-22 标题:Method for synthesis of fatty acids 发明人:CESCUT JULIEN; URIBELARREA JEAN-LOUIS; GUILLOUET STEPHANE; MOLINA-JOUVE CAROLE; SAGNAK RANA 权利人:INST NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT; AGRONOMIQUE INST NAT RECH; FIDOP (FONDS DE DEV DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX) 摘要:Disclosed is a method for synthesis of fatty acids by culturing a eukaryotic microorganism from the fungi kingdom, that is naturally oleaginous or rendered oleaginous. The culture is performed in the presence a fatty acid synthase inhibitor in the culture medium.
专利号:WO-2025038767-A1 优先权日:2023-08-14 标 题:Cell-free synthesis platform for synthetically dimierized, clickable fragment antigen-binding (fab) fragments 发明人:THAMES ARIEL; RISCHE CLAYTON; JEWETT MICHAEL; BOCHNER BRUCE 权利人:UNIV NORTHWESTERN 摘要:Disclosed are components, systems, methods, and kits for synthesis of diamerized, clickable antigen binding fragments, such as Fab fragments, and uses thereof. The components, systems, methods, and kits disclosed herein utilize cell-free protein synthesis (CFPS) systems and methods to produce clickable antigen binding fragments.
1: Jain A, Mehta R, Al-Ani M, Hill JA, Winchester DE. Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review. J Card Fail. 2015 Oct 20. pii: S1071-9164(15)01129-X. doi: 10.1016/j.cardfail.2015.10.005. [Epub ahead of print] Review. doi: 10.1016/j.ejpn.2015.04.008. Epub 2015 May 14. Review. doi: 10.3390/nu7042415. Review. 4: Steinberg A, Gorman E, Tannenbaum J. Thiamine deficiency in stem cell transplant patients: a case series with an accompanying review of the literature. Clin Lymphoma Myeloma Leuk. 2014 Sep;14 Suppl:S111-3. doi: 10.1016/j.clml.2014.06.009. Review. doi: 10.1111/imj.12522. Review. doi: 10.4239/wjd.v5.i3.288. Review. 7: Afadlal S, Labetoulle R, Hazell AS. Role of astrocytes in thiamine deficiency. Metab Brain Dis. 2014 Dec;29(4):1061-8. doi: 10.1007/s11011-014-9571-y. Epub 2014 Jun 15. Review. doi: 10.1007/s10545-014-9712-9. Epub 2014 May 1. Review. doi: 10.1007/s11011-014-9509-4. Epub 2014 Mar 4. Review. doi: 10.1016/j.lfs.2013.12.029. Epub 2014 Jan 4. Review. Review. French. Available from http://www.ncbi.nlm.nih.gov/books/NBK169615/ doi: 10.1155/2013/309143. eCollection 2013. Review.