CAS: 668270-12-0; (R)-8-(3-Aminopiperidin-1-yl)-7-(But-2-Yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-1H-Purine-2,6(3H,7H)-Dione

上下游产品

(R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine2,6-dione (R)-piperidine-3-carboxylic acid ethyl ester*l-tartaric acid 2-bromo-1-(but-2-ynyl)-4-methyl-6-((4-methylquinazolin-2-yl)methyl)-1H-imidazo[4,5-b]pyridine-5,7-(4H,6H)-dione 3-(R)-aminopiperidine dihydr°Chloride

1-甲基尿嘧啶置于甲醇,水,碳酸氢钠,三乙胺,Potassium Iodide,Lithium Hexamethyldisilazane体系中,用 N-甲基吡咯烷酮,对二甲苯,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 1.52H,反应生成 利拉利汀
参考文献:一种利格列汀中间体化合物ⅴ
标题:一种利格列汀中间体化合物ⅴ
摘要:本发明属于医药化工领域,本发明提供了一种利格列汀中间体化合物ⅴ及利用该中间体ⅴ合成利格列汀重要中间体,解决了现有技术中利格列汀中间体自身偶合及有较大杂质产生的现象,本发明合成的新中间体化合物ⅴ,收率高,操作简单,生产成本显著降低,适合工业化生产.

专利信息

专利号:US-11401269-B2
优先权日:2018-05-15
标 题 :Intermediates and processes for the preparation of Linagliptin and its salts
发明人：CIANCIMINO CRISTINA; TRAGNI MICHELE; VIGO DANIELE; PICCOLO ORESTE
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:Disclosed are new intermediates for the synthesis of Linagliptin and of its salts and a process for its preparation involving said intermediates.

专利号:US-5012029-A
优先权日:1989-10-16
标 题:Conversion of methane
发明人：HAN SCOTT; MARTENAK DANIEL J; PALERMO ROBERT E; WALSH DENNIS E
权利人:MOBIL OIL CORP
摘要:A mixture of organic compounds comprising a major amount of liquid hydrocarbons, mostly aromatic, is formed by the direct partial oxidation of methane in the presence of a ZSM-5 catalyst. The reaction conditions are substantially the same as those required for the direct homogeneous partial oxidation to methanol. However, liquid hydrocarbon formation depends on the presence of a small amount of an impurity such as propane or propylene in the feed; in the absence of such, only methanol is formed. With such modifier present, controls of reaction parameters, e.g., temperature, permits synthesis of both methanol and liquid hydrocarbons in desired proportions. Properly processed natural gas can serve to provide methane and at least part of the reaction modifier.

专利号:WO-2015067539-A1
优先权日:2013-11-06
标 题:Process and intermediates for the preparation of linagliptin
发明人：GABOARDI MAURO; CASTALDI GRAZIANO; CASTALDI MARTA
权利人:CHEMELECTIVA S R L
摘要:The present invention relates to a process for the synthesis of Linagliptin and intermediates useful for its preparation.

专利号:US-2012282255-A1
优先权日:2011-04-07
标题 :Methods and compositions for the treatment of alcoholism and alcohol dependence
发明人：PLUCINSKI GREG
权利人:PLUCINSKI GREG
摘要:The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

专利号:US-2024342244-A1
优先权日:2021-07-28
标 题:Isthmin Protein Therapeutics for the Treatment of Non-Alcoholic Fatty Liver Disease
发明人：SVENSSON KATRIN JENNIFER; VOILQUIN LAETITIA
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the treatment of one or both of type 2 diabetes and fatty liver disease, e.g. non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The adipokine Isthmin-1 (ISM1) protein increases adipose glucose uptake while suppressing hepatic lipid synthesis.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.