临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 66722-44-9

Bisoprolol

中文名称: 比索洛尔
CAS号:66722-44-9
分子式: C18H31NO4 分子量: 325.44
产品形式: Free Base
研发状态: Recruiting
研发用途: Heart Failure
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: April 4 2023
研发阶段: --
Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.

CAS: 666843-10-3

Mizagliflozin (KWA 0711)

CAS号:666843-10-3
分子式: C28H44N4O8 分子量: 564.67
产品形式: Free base
研发状态: Completed
研发用途: Postbariatric Hypoglycemia
研究机构: Vogenx Inc.
研发日期: September 13 2022
研发阶段: Phase 2
Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.

CAS: 66575-29-9

Colforsin

中文名称:佛司可林
CAS号:66575-29-9
分子式: C22H34O7 分子量: 410.50
产品形式: free base
研发状态: Withdrawn
研发用途: Cystic Fibrosis
研究机构: Universitaire Ziekenhuizen KU Leuven; Vertex Pharmaceuticals Incorporated; KU Leuven; University of Lisbon
研发日期: March 1 2020
研发阶段: Not Applicable
Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.

CAS: 665-66-7

Amantadine HCl

中文名称:盐酸金刚烷胺
CAS号:665-66-7
分子式: C10H17N.HCl 分子量: 187.70
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Glioblastoma Multiforme
研究机构: CancerCare Manitoba; University of Manitoba; The Metabolomics Innovation Centre; BioMark Diagnostics Inc.; Canadian Institutes of Health Research (CIHR)
研发日期: December 2 2020
研发阶段: Not Applicable
Amantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus.

CAS: 6645-46-1

L-Carnitine hydrochloride

中文名称:左旋肉碱盐酸盐
CAS号:6645-46-1
分子式: C7H16ClNO3 分子量: 197.66
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Diabetic Peripheral Neuropathic Pain
研究机构: Haisco Pharmaceutical Group Co. Ltd.
研发日期: May 1 2023
研发阶段: Not Applicable
L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.

CAS: 664334-36-5

Motixafortide (BL-8040)

CAS号:664334-36-5
分子式: C97H144FN33O19S2 分子量: 2159.52
产品形式: free base
研发状态: Withdrawn
研发用途: Chronic Myeloid Leukemia
研究机构: Sheba Medical Center
研发日期: Nov-14
研发阶段: Phase 1 : Phase 2
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.