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临床前CDMO研发化合物筛选
GSK923295
中文名称:3-氯-n-((s)-1-(2-(二甲基氨基)乙酰氨基)-3-(4-(8-((s)-1-羟基乙基)咪唑并[1,2-a]吡啶-2-基)苯基)丙烷-2-基)-4-异丙氧基苯甲酰胺
CAS号:1088965-37-0
分子式: C32H38ClN5O4 分子量: 592.13
产品形式: free base
研发状态: Completed
研发用途: Cancer
研究机构: GlaxoSmithKline
研发日期: June 25 2007
研发阶段: Phase 1
GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.
LY2510924
CAS号:1088715-84-7
分子式: C62H88N14O10 分子量: 1189.45
产品形式: Free base
研发状态: Terminated
研发用途: Solid Tumor
研究机构: Eli Lilly and Company; AstraZeneca
研发日期: Sep-16
研发阶段: Phase 1
LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L.
Lanreotide
中文名称:兰瑞肽
CAS号:108736-35-2
分子式: C54H69N11O10S2 分子量: 1096.32
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Gastro-enteropancreatic Neuroendocrine Tumor; Acromegaly
研究机构: Ipsen
研发日期: March 26 2024
研发阶段: --
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.
Omipalisib (GSK2126458)
中文名称:奥米利塞
CAS号:1086062-66-9
分子式: C25H17F2N5O3S 分子量: 505.50
产品形式: free base
研发状态: Completed
研发用途: Idiopathic Pulmonary Fibrosis
研究机构: GlaxoSmithKline
研发日期: March 8 2013
研发阶段: Phase 1
Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.
Noradrenaline bitartrate monohydrate
中文名称:重酒石酸去甲肾上腺素
CAS号:108341-18-0
分子式: C8H11NO3.C4H6O6.H2O 分子量: 337.28
产品形式: bitartrate monohydrate
研发状态: Not yet recruiting
研发用途: Heart Failure
研究机构: Nanjing First Hospital Nanjing Medical University
研发日期: June 1 2024
研发阶段: --
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
LY2584702 Tosylate
中文名称:LY-2584702对甲苯磺酸盐
CAS号:1082949-68-5
分子式: C28H27F4N7O3S 分子量: 617.62
产品形式: free base
研发状态: Completed
研发用途: Cancer
研究机构: Eli Lilly and Company
研发日期: Nov-10
研发阶段: Phase 1
LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
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