CAS: 1086062-66-9; 2,4-Difluoro-N-(2-Methoxy-5-(4-(Pyridazin-4-yl)Quinolin-6-yl)Pyridin-3-yl)Benzenesulfonamide

上下游产品

CAS号1086063-46-8 N-(5-Bromo-2-me... | CAS号1086063-18-4 6-溴-4-(吡嗪-4-基)喹啉 | CAS号884495-39-0 3-氨基-5-溴-2-甲氧基吡啶 | CAS号67443-38-3 5-溴-2-氯-3-硝基吡啶 | CAS号152684-30-5 2-甲氧基-3-硝基-5-溴吡啶 | CAS号15862-34-7 5-溴-2-羟基-3-硝基吡啶 | CAS号65340-70-7 4-氯-6-溴喹啉 | CAS号927801-23-8 6-溴-4-碘喹啉 | CAS号1086062-75-0 6-bromo-4-chlor... | CAS号145369-94-4 6-溴-4-羟基喹啉

📜6-溴-4-碘-喹啉置于1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物,Potassium Acetate,Sodium Carbonate体系中,用 1,4-二氧六环 用作溶剂,化学反应生成芸香苷
参考文献:[11C]Gsk2126458 And [18F]Gsk2126458,The First Radiosynthesis Of New Potential Pet Agents For Imaging Of Pi3K And Mtor In Cancers
标题:[11C]Gsk2126458 And [18F]Gsk2126458,The First Radiosynthesis Of New Potential Pet Agents For Imaging Of Pi3K And Mtor In Cancers
摘要:Gsk2126458 Is A Highly Potent Inhibitor Of Phosphoinositide 3-Kinase (Pi3K) And Mammalian Target Of Rapamycin (Mtor) With Low Picomolar To Subnanomolar Activity. [c-11]Gsk2126458 And [f-18]Gsk212 6458,New Potential Pet Agents For Imaging Of Pi3K And Mtor In Cancer,Were First Designed And Synthesized In 40-50% And 20-30% Decay Corrected Radiochemical Yield,And 370-740 And 37-222 Gbq/lmol Specific Activity At End Of Bombardment (Eob),Respectively. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.12.136

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2024342244-A1
优先权日:2021-07-28
标 题:Isthmin Protein Therapeutics for the Treatment of Non-Alcoholic Fatty Liver Disease
发明人：SVENSSON KATRIN JENNIFER; VOILQUIN LAETITIA
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the treatment of one or both of type 2 diabetes and fatty liver disease, e.g. non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The adipokine Isthmin-1 (ISM1) protein increases adipose glucose uptake while suppressing hepatic lipid synthesis.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2022047711-A1
优先权日:2018-12-10
标题 :Photocrosslinking peptides for site specific conjugation to fc-containing proteins
发明人：SADOWSKY JACK; ZACHARIAS NEELIE TYANA
权利人:GENENTECH INC
摘要:Provided herein are peptides having a photocrosslinking moiety useful for the synthesis of antibody-drug conjugates as well as methods of making and using such conjugates.