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临床前CDMO研发化合物筛选
PF-04620110
中文名称:反式-4-[4-(4-氨基-7,8-二氢-5-氧代嘧啶并[5,4-f][1,4]氧氮杂卓-6(5H)-基)苯基]环己烷乙酸
CAS号:1109276-89-2
分子式: C21H24N4O4 分子量: 396.44
产品形式: free base
研发状态: Completed
研发用途: Type 2 Diabetes Patients
研究机构: Pfizer
研发日期: Feb-11
研发阶段: Phase 1
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
Entrectinib (RXDX-101)
中文名称:恩曲替尼
CAS号:1108743-60-7
分子式: C31H34F2N6O2 分子量: 560.64
产品形式: free base
研发状态: Recruiting
研发用途: Solid Tumor; Haematological Malignancy; Malignancy; Malignant Neoplasm; Lymphoproliferative Disorders; Neoplasms by Histologic Type; Neoplasms by Site; Cancer; Brain Neoplasms; Melanoma; Glioma
研究机构: Cancer Research UK; University of Manchester; University of Birmingham; Royal Marsden NHS Foundation Trust; Hoffmann-La Roche
研发日期: Jun-24
研发阶段: Phase 2 : Phase 3
Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.
Meclizine 2HCl
中文名称: 盐酸美克洛嗪
CAS号:1104-22-9
分子式: C25H27Cl2N2.2HCl 分子量: 463.87
产品形式: Dihydrochloride
研发状态: Unknown status
研发用途: Seasickness; Meclizine
研究机构: Medical Corps Israel Defense Force
研发日期: September 1 2020
研发阶段: Phase 4
Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.
Fumaric acid
中文名称:富马酸,反丁烯二酸
CAS号:110-17-8
分子式: C4H4O4 分子量: 116.07
产品形式: free base
研发状态: Recruiting
研发用途: Beta-thalassemia
研究机构: Bristol-Myers Squibb
研发日期: October 17 2022
研发阶段: Phase 2
Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.
Succinic acid
中文名称:琥珀酸; 丁二酸
CAS号:110-15-6
分子式: C4H6O4 分子量: 118.09
产品形式: free base
研发状态: Completed
研发用途: Noise Exposure; Sleep Disturbance; Sleep Hygiene; Metabolic Disturbance; Cognitive Change
研究机构: Göteborg University; University of Pennsylvania; University of Manitoba
研发日期: April 24 2022
研发阶段: Not Applicable
Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
Indoximod (NLG-8189）
中文名称:吲哚莫德
CAS号:110117-83-4
分子式: C12H14N2O2 分子量: 218.25
产品形式: Free Base
研发状态: Terminated
研发用途: Melanoma
研究机构: NewLink Genetics Corporation; Lumos Pharma
研发日期: December 8 2017
研发阶段: Phase 2
Indoximod (NLG-8189, 1-Methyl-D-tryptophan, 1-MT), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
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