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临床前CDMO研发化合物筛选
Letrozole (CGS 20267)
中文名称: 来曲唑
CAS号:112809-51-5
分子式: C17H11N5 分子量: 285.30
产品形式: free base
研发状态: Not yet recruiting
研发用途: Leiomyoma Uterine; Leiomyoma; Fibroid; Fibroid Uterus
研究机构: University of California San Francisco; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
研发日期: May 13 2024
研发阶段: Phase 4
Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
Pioglitazone HCl
中文名称: 盐酸吡格列酮
CAS号:112529-15-4
分子式: C19H20N2O3S.HCl 分子量: 392.90
产品形式: Hydrochloride
研发状态: Not yet recruiting
研发用途: ANCA Associated Vasculitis; Rapidly Progressive Glomerulonephritis; Crescentic Glomerulonephritis
研究机构: Assistance Publique - Hôpitaux de Paris; Ministry of Health France
研发日期: Jul-23
研发阶段: Phase 3
Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
Sitravatinib (MGCD516)
中文名称:司曲替尼
CAS号:1123837-84-2
分子式: C33H29F2N5O4S 分子量: 629.68
产品形式: free base
研发状态: Completed
研发用途: Healthy Adults
研究机构: Mirati Therapeutics Inc.
研发日期: July 7 2021
研发阶段: Phase 1
Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
Quetiapine (ICI-204636) fumarate
中文名称:富马酸喹硫平
CAS号:111974-72-2
分子式: C46H54N6O8S2 分子量: 883.09
产品形式: Fumarate
研发状态: Unknown status
研发用途: Bipolar Disorder
研究机构: Guangzhou Mental Hospital; First Affiliated Hospital of Jinan University; Second Affiliated Hospital of Guangzhou Medical University; Guangzhou mental Hospital Attached to Guangzhou Civil Affairs Bureau
研发日期: Dec-08
研发阶段: Phase 4
Quetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
Quetiapine
中文名称:喹硫平
CAS号:111974-69-7
分子式: C21H25N3O2S 分子量: 383.51
产品形式: Free Base
研发状态: Completed
研发用途: Delirium
研究机构: Ain Shams University
研发日期: March 1 2023
研发阶段: Phase 2
Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.
L-Arginine HCl (L-Arg)
中文名称:L-精氨酸盐酸盐
CAS号:1119-34-2
分子式: C6H14N4O2.HCl 分子量: 210.66
产品形式: HCl
研发状态: Not yet recruiting
研发用途: Chronic Obstructive Pulmonary Disease (COPD)
研究机构: Universitätsklinikum Hamburg-Eppendorf
研发日期: March 1 2024
研发阶段: --
L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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