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临床前CDMO研发化合物筛选
Telotristat Etiprate (LX 1606 Hippurate)
中文名称: LX1606马尿酸盐
CAS号:1137608-69-5
分子式: C27H26ClF3N6O3.C9H9NO3 分子量: 754.15
产品形式: Hippuric acid
研发状态: Completed
研发用途: Renal Impairment
研究机构: Ipsen
研发日期: February 9 2018
研发阶段: Phase 1
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.
Chlorprothixene
中文名称:氯普噻吨
CAS号:113-59-7
分子式: C18H18ClNS 分子量: 315.86
产品形式: free base
研发状态: Recruiting
研发用途: Obesity Morbid
研究机构: Norwegian University of Science and Technology; St. Olavs Hospital; Volvat Medisinsk Senter Stokkan; Namsos Hospital; Alesund Hospital
研发日期: January 2 2018
研发阶段: --
Chlorprothixene(Minithixen,Truxal) has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
Imipramine HCl
中文名称:丙咪嗪盐酸盐
CAS号:113-52-0
分子式: C19H25ClN2 分子量: 316.87
产品形式: hydrochloride
研发状态: Recruiting
研发用途: Rosacea
研究机构: Wright State University
研发日期: February 27 2024
研发阶段: Phase 2
Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
Moxidectin
中文名称:莫西菌素
CAS号:113507-06-5
分子式: C37H53NO8 分子量: 639.82
产品形式: free base
研发状态: Active not recruiting
研发用途: Onchocerciasis
研究机构: Medicines Development for Global Health
研发日期: May 3 2021
研发阶段: Phase 3
Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
Dasabuvir (ABT-333)
中文名称:达沙布韦
CAS号:1132935-63-7
分子式: C26H27N3O5S 分子量: 493.57
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteer
研究机构: AbbVie
研发日期: Sep-15
研发阶段: Phase 1
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.
Donafenib (Sorafenib D3)
中文名称:索拉非尼-d3
CAS号:1130115-44-4
分子式: C21H13D3ClF3N4O3 分子量: 467.84
产品形式: free base
研发状态: Recruiting
研发用途: Advanced Gastrointestinal Tumors
研究机构: Suzhou Zelgen Biopharmaceuticals Co.Ltd; Jiangsu Alphamab Biopharmaceuticals Co. Ltd
研发日期: January 19 2021
研发阶段: Phase 1 : Phase 2
Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.
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