CAS: 113507-06-5; (2R,2A'E,2A1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17A'R,20'R,20A'R)-2A1',20'-Dihydroxy-4-(Methoxyimino)-5,6',8',19'-Tetramethyl-6-((E)-4-Methylpent-2-En-2-yl)-2A1',3,4,5,6,6',7',10',11',14',15',17A',20',20A'-Tetradecahydro-2'H,17'H-Spiro[pyran-2,13'-[11,15]Me

上下游产品

N-methoxylamine hydr°Chloride 23-oxynemadectin 38H52O9C38H52O9 38H54O9C38H54O9

5-Oxo(4-Chlorophenoxyacetyl)-2,3-Oxonemadectin置于甲醇,Sodium Acetate,Sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应生成莫西菌素
参考文献:一种化学合成莫西克汀的方法
标题:一种化学合成莫西克汀的方法
摘要:一种化学合成莫西克汀的方法,属于药物化学领域.该方法以尼莫克汀为原料,与作为上保护试剂的4-氯苯氧基乙酰氯进行反应,通过上保护,氧化,肟化,去保护四步反应,制备莫西克汀;并且肟化和去保护的反应顺序可以互换,不影响最终的反应产物.在上述反应过程中,上保护,氧化及肟化这三步的产物可以通过甲醇等重结晶提纯,因而该方法降低了对原料纯度的要求,简化了操作流程,降低了反应成本.

专利信息

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人：FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

专利号:EP-1306084-B1
优先权日:1998-06-09
标 题 :Compositions for the control of parasitic infestations in fish
发明人：ALEXANDER SVEIN; EVENSEN OYSTEIN; SYVERTSEN CHRISTIAN; MARTINSEN BERNT
权利人:PHARMAQ AS
摘要:Injectable compositions comprising antiparasitically active chitin synthesis inhibitor substances are described, for controlling parasitic infestations including infestations with sea lice and isopod species in farmed fish. The compositions are optionally formulated in a fish vaccine. The antiparasitically active chitin synthesis inhibitor substances protect the fish against parasites for a substantial period of time after injection. Useful embodiments include compositions with lufenuron that confer protection against new parasitic infestation for an extended period of time after treatment.

专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:US-8937089-B2
优先权日:2004-07-01
标 题:Synergistic mixtures of anthranilamide invertebrate pest control agents
发明人：ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN
权利人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN; DU PONT
摘要:Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof n n n n n n n n n n n n andn na component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.n n n n n n Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.