CAS: 1109276-89-2; 2-(Trans-4-(4-(4-Amino-5-Oxo-7,8-Dihydropyrimido[5,4-F][1,4]Oxazepin-6(5H)-yl)Phenyl)Cyclohexyl)Acetic Acid

上下游产品

methyl {trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-(5H)-yl)phenyl]cyclohexyl}acetate2-{trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}-N-(methylsulfonyl)acetamide 4-amino-6-{4-[trans-4-(2-oxo-2-pyrrolidin-1-ylethyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one trans-N-acetyl-N'-(2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenz°Cyclohepten-6-yl)phenyl]cyclohexyl}acetyl)hydrazine trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenz°Cyclohepten-6-yl)phenyl]cyclohexyl}-N-methylacetamide

📜Cyclohexaneacetic Acid,4-[4-(4-Amino-7,8-Dihydro-5-Oxopyrimido[5,4-F][1,4]Oxazepin-6(5H)-yl)Phenyl]-,Methyl Ester,Trans-以94.8的收率获得pf-04620110; 反式-4-[4-(4-氨基-7,8-二氢-5-氧代嘧啶并[5,4-F][1,4]氧氮杂卓-6(5H)-基)苯基]环己烷乙酸
参考文献:Acs Med. Chem. Lett. 2011,2,407-412
标题:Acs Med. Chem. Lett. 2011,2,407-412

专利信息

专利号:US-12016933-B2
优先权日:2020-11-25
标题:Method for stimulating axonal regeneration
发明人：YANG CHAO; WANG XU; LIU KAI
权利人:UNIV HONG KONG SCIENCE & TECH
摘要:A method of promoting axonal regeneration can include directing neuronal lipid synthesis away from triglyceride synthesis and toward phospholipid synthesis. The method can include administering to the patient a therapeutically effective amount of an inhibitor compound selected from the group consisting of a Lipin-1 inhibitor, a diglyceride acyltransferase inhibitor, and combinations thereof or administering a gene editing therapy to the patient that reduces expression of LIPIN1 or a diglyceride acyltransferase gene.