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临床前CDMO研发化合物筛选
Sildenafil Citrate
中文名称:枸橼酸西地那非
CAS号:171599-83-0
分子式: C22H30N6O4S.C6H8O7 分子量: 666.70
产品形式: Citrate
研发状态: Completed
研发用途: Edema Pulmonary; Immersion; Diving
研究机构: Duke University; United States Department of Defense
研发日期: July 15 2019
研发阶段: Phase 2
Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.
Tadalafil (IC351)
中文名称:他达那非
CAS号:171596-29-5
分子式: C22H19N3O4 分子量: 389.40
产品形式: free base
研发状态: Not yet recruiting
研发用途: Duchenne Muscular Dystrophy; Duchenne Disease; Muscular Dystrophy; Muscular Dystrophy in Children; Vasodilation; Exercise; DMD
研究机构: University of Florida; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
研发日期: Mar-24
研发阶段: Phase 2
Tadalafil (IC351) is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11
Dalbavancin
中文名称: 达巴万星
CAS号:171500-79-1
分子式: C88H100Cl2N10O28 分子量: 1816.69
产品形式: free base
研发状态: Recruiting
研发用途: Osteoarticular Infection
研究机构: Centre Hospitalier Universitaire de Nice
研发日期: March 7 2022
研发阶段: Not Applicable
Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.
Posaconazole (SCH 56592)
中文名称:泊沙康唑
CAS号:171228-49-2
分子式: C37H42F2N8O4 分子量: 700.78
产品形式: free base
研发状态: Not yet recruiting
研发用途: Acute Respiratory Tract Infection
研究机构: European Clinical Research Alliance for Infectious Diseases (ECRAID); UMC Utrecht; University of Oxford; Universiteit Antwerpen
研发日期: Feb-24
研发阶段: --
Posaconazole (SCH 56592,POS,Noxafil) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
Roblitinib (FGF401)
中文名称:8-二氮杂萘-1(2H)-甲酰胺
CAS号:1708971-55-4
分子式: C25H30N8O4 分子量: 506.56
产品形式: free base
研发状态: Completed
研发用途: Hepatocellular Carcinoma (HCC); Solid Malignancies
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: December 29 2014
研发阶段: Phase 1 : Phase 2
Roblitinib (FGF401) is an FGFR4-selective inhibitor with an IC50 of 1.9 nM. It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.
Efaproxiral Sodium
中文名称:乙丙昔罗钠
CAS号:170787-99-2
分子式: C20H23NO4.Na 分子量: 363.38
产品形式: Sodium salt
研发状态: Withdrawn
研发用途: Brain and Central Nervous System Tumors
研究机构: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI)
研发日期: Not Applicable
研发阶段:
Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.
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