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临床前CDMO研发化合物筛选
Elafibranor
中文名称:2-[2,6-二甲基-4-[(1E)-3-[4-(甲硫基)苯基]-3-氧代-1-丙烯-1-基]苯氧基]-2-甲基丙酸
CAS号:923978-27-2
分子式: C22H24O4S 分子量: 384.49
产品形式: free base
研发状态: Completed
研发用途: Healthy Participants
研究机构: Ipsen
研发日期: October 27 2022
研发阶段: Phase 1
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.
Simeprevir (TMC435)
中文名称: 司美匹韦
CAS号:923604-59-5
分子式: C38H47N5O7S2 分子量: 749.94
产品形式: free base
研发状态: Withdrawn
研发用途: Hepatic Impairment
研究机构: Janssen Research & Development LLC
研发日期: September 11 2017
研发阶段: Phase 1
Simeprevir (TMC-435, TMC-435350) is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes(genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.
Navitoclax (ABT-263)
中文名称:生根粉263
CAS号:923564-51-6
分子式: C47H55ClF3N5O6S3 分子量: 974.61
产品形式: free base
研发状态: Recruiting
研发用途: High Grade Serous Carcinoma; Triple Negative Breast Cancer; Ovarian Cancer
研究机构: Sunnybrook Health Sciences Centre; Exactis Innovation; Centre hospitalier de l''Université de Montréal (CHUM); Princess Margaret Hospital Canada
研发日期: November 9 2022
研发阶段: Phase 1
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
Iodixanol
中文名称: 碘克沙醇
CAS号:92339-11-2
分子式: C35H44I6N6O15 分子量: 1550.18
产品形式: Free base
研发状态: Unknown status
研发用途: Kidney Failure Chronic
研究机构: Yong Huo; Peking University First Hospital
研发日期: Apr-12
研发阶段: Phase 4
Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.
Nilotinib hydrochloride monohydrate
中文名称: 尼罗替尼单盐酸盐单水合物
CAS号:923288-90-8
分子式: C28H25ClF3N7O2 分子量: 583.99
产品形式: Hydrochloride monohydrate
研发状态: Not yet recruiting
研发用途: CML Chronic Phase; Chronic Myeloid Leukemia Chronic Phase; Chronic Myeloid Leukemia BCR/ABL-Positive; Chronic Myeloid Leukemia
研究机构: Gruppo Italiano Malattie EMatologiche dell''Adulto; Fundacion Espanola para la Curacion de la Leucemia Mieloide Cronica
研发日期: Sep-24
研发阶段: Phase 2
Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
Toluidine Blue O
中文名称:甲苯胺蓝O
CAS号:92-31-9
分子式: C15H16N3S.Cl 分子量: 305.83
产品形式: chloride
研发状态: Recruiting
研发用途: Cartilage Damage; Osteoarthritis Hip
研究机构: Insel Gruppe AG University Hospital Bern
研发日期: September 1 2022
研发阶段: --
Toluidine Blue O (Toluidine Blue) is a thiazine dye of the quinone-imine family and is cationic in nature. Toluidine Blue O along with light-emitting diode has been used as a photosensitizer to control in vitro biofilms and to kill gram-negative bacteria. Toluidine Blue has wide applications in vital staining in living tissues and used as a special stain.
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