CAS: 92339-11-2; 5,5'-((2-Hydroxypropane-1,3-Diyl)Bis(Acetylazanediyl))Bis(N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodoisophthalamide)

上下游产品

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide epichlorohydrin 1,3-Dichloro-2-propanol 1,3-dichloro-2-(6-(3,4,5,6-tetrahydro-2H-pyranoxy))propane

Ethyl 5-Amino-2,4,6-Triiodoisophthalate置于三乙胺体系中,用 甲苯 作为反应溶剂,化学反应生成 碘克沙醇
参考文献:一种碘克沙醇的制备方法
标题:一种碘克沙醇的制备方法
摘要:本发明提供一种碘克沙醇的制备方法,包括如下步骤:(1)5‑氨基‑2,4,6‑三碘间苯二甲酸酯(I)与醋酐反应得到5‑乙酰氨基‑2,4,6‑三碘间苯二甲酸酯(II);(2)5‑乙酰氨基‑2,4,6‑三碘间苯二甲酸酯(II)与1,3‑二氯‑2‑丙醇(或1,3‑二溴‑2‑丙醇,表氯醇)反应,反应生成5,5'‑((2‑羟基丙烷‑1,3‑二基)双(乙酰胺基))双(2,4,6‑三碘间苯二甲酸乙酯;(3)5,5'‑((2‑羟基丙烷‑1,3‑二基)双(乙酰胺基))双(2,4,6‑三碘间苯二甲酸乙酯与1‑氨基‑2,3‑丙二醇发生氨解反应得到碘克沙醇(Iv).

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-7696381-B1
优先权日:2009-07-21
标题 :Alternative dimerisation reagents for synthesis of iodixanol
发明人：BERG ARNE; DUGSTAD HARALD; GACEK MICHEL; GULBRANDSEN TRYGVE; STRANDE PER
权利人:GE HEALTHCARE AS
摘要:This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?) to iodixanol.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.

专利号:US-8962887-B2
优先权日:2009-07-21
标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
发明人：HOMESTAD OLE MAGNE
权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.

专利号:US-2011021822-A1
优先权日:2009-07-21
标题:continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
发明人：ASKILDSEN ARNE; CERVENKA JAN; HUSSAIN KHALID; SORENSEN THORE JARLE; MALTHE-SORENSSEN DIDRIK
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by crystallisations, filtration, and washing of Compound A.