CAS: 92-31-9; Toluidine Blue

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CAS号636-21-5 邻甲苯胺盐酸盐 | CAS号536-46-9 N,N-二甲基对苯二胺,盐酸盐

2-甲基苯胺 盐酸盐,4-Dimethylaminophenylamine Dihydrochloride置于盐酸,Potassium Dichromate,Aluminum(Iii) Sulfate,Copper(II) Sulfate,Zinc(II) Chloride,Sodium Thiosulfate体系中,用 水 作为反应溶剂,化学反应生成 3-Amino-4-Methyl-7-(Methylamino)Phenothiazin-5-Ium Chloride,3-Amino-7-(Dimethylamino)-4-Methylphenothiazin-5-Ium Chloride,3-Amino-2-Methyl-7-(Methylamino)Phenothiazin-5-Ium Chloride,甲苯胺蓝
参考文献: Toluidine Blue O Drug Substance And Use Thereof For In Vivo Staining And Chemotherapeutic Treatment Of Dysplastic Tissues[fr] Medicaments Au Bleu De Toluidine O Et Leur Utilisation Pour La Coloration In Vivo Et Le Traitement Chimiotherapeutique De Tissus Dysplasiques
标题: Toluidine Blue O Drug Substance And Use Thereof For In Vivo Staining And Chemotherapeutic Treatment Of Dysplastic Tissues[fr] Medicaments Au Bleu De Toluidine O Et Leur Utilisation Pour La Coloration In Vivo Et Le Traitement Chimiotherapeutique De Tissus Dysplasiques

专利信息

专利号:US-5824472-A
优先权日:1986-03-24
标 题 :Process for the synthesis of sugar nucleotides using recombinant-DNA methods
发明人：BETLACH MICHAEL R; DOHERTY DANIEL H; VANDERSLICE REBECCA W
权利人:MONSANTO CO
摘要:A recombinant-DNA mediated method for the synthesis of sugar nucleotides is disclosed. This method utilizes portable DNA sequences capable of directing the microbial synthesis of various enzymes that catalyze the synthesis of sugar nucleotides, including UDP-glucose, UDP-glucuronic acid and GDP-mannose. The sugar moieties of these sugar nucleotides may subsequently be incorporated into industrially-useful polysaccharides such as xanthan gum. It has been found that vectors containing the portable DNA sequences described herein are capable both of causing sugar nucleotide production in microorganisms previously incapable of such synthesis and of causing increased sugar nucleotide production in organisms capable of synthesizing small quantities of these compounds. In particular, plasmids pAS7, pAS9 and pTS13 are disclosed. These plasmids are capable of directing sugar nucleotide synthesis in various hosts, including Xanthomonas sp. such as X. campestris and other organisms such as E. coli and various Pseudomonas sp.

专利号:US-6515039-B1
优先权日:1998-08-28
标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
发明人：ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:POLY AN GMBH
摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

专利号:US-2025205370-A1
优先权日:2022-03-19
标 题:Synthesis of toluidine blue o and a kit for mucosal application
发明人：PANDA SWAGATIKA
权利人:PANDA SWAGATIKA
摘要:The present invention describes synthesis of Toluidine blue O for a formulation to be used for screening and biopsy site identification in oral cancer. The invention discloses two formulations and a method of delivery of the said formulations via a kit. The method described is a reproducible method of synthesis of pharmaceutical grade Toluidine blue O of acceptable purity and good colorimetric value. The present invention also discloses a kit that includes one formulation of a cleaning solution containing an organic acid and another formulation that is a vital stain formulation. The kit is packaged as a dual chamber sprayer having two pump dispensers, that facilitates ready to use, convenient dental chair side delivery, and allows mass screening.

专利号:US-10150160-B2
优先权日:2014-12-04
标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
发明人：PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

专利号:US-6086852-A
优先权日:1997-11-13
标 题:In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
发明人：BURKETT DOUGLAS D
权利人:ZILA INC
摘要:PCT No. PCT/US97/20981 Sec. 371 Date May 20, 1999 Sec. 102(e) Date May 20, 1999 PCT Filed Nov. 13, 1997 PCT Pub. No. WO99/25388 PCT Pub. Date May 27, 1999N-demethylated and N,N-demethylated derivatives of toluidine blue O and compositions which include these derivatives and the conformational isomers of toluidine blue O. Improved methods for the detection of dysplastic oral tissue using such compositions. Processes for synthesis of toluidine blue O products, in which a complexing agent is introduced prior to the last stage of oxidation of a three-step synthesis from N,N-dimethyl- rho -phenylenediamine. An HPLC method for characterizing toluidine blue O products in which the mobile phase is an aqueous solution of an organic acid.

专利号:US-2008311580-A1
优先权日:2004-03-09
标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis
发明人：ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN
权利人:COMMW SCIENT IND RES ORG
摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.