近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式：PROTAC/分子胶降解剂：通过诱导靶蛋白泛素化降解发挥作用，而非传统“占位驱动”抑制。这类分子的项目整合需要同时考量靶点配体、E3连接酶配体及连接子的三元复合物优化，临床前到临床的转化难度显著增加。多肽/环肽药物：介于小分子与生物制品之间，兼具高选择性与口服可用性潜力。项目整合中需重点解决稳定性、递送及生产工艺放大问题。抗体-药物偶联物（ADC）：作为“生物导弹”，ADC的项目整合涉及抗体、连接子、有效载荷三部分的协同优化，需要跨学科团队的深度整合。小核酸药物（siRNA/ASO）：通过基因沉默机制发挥作用，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。展望未来，新型API项目的整合将呈现以下趋势：第一，AI贯穿全链条。从靶点发现、分子优化到临床开发、上市后监测，AI将成为贯穿API全生命周期的核心工具。第二，数据资产化。临床研究数据和真实世界数据将从“辅助工具”升级为“核心资产”，数据驱动的决策将成为项目整合的标准范式。第三，开放整合生态。API经济的成熟正在推动制药企业从“封闭研发”走向“开放协作”，通过API接口与外部数据源、技术平台、CRO/CDMO实现无缝对接. 而API技术——无论是数据接口还是组织协作的“应用程序接口”——正成为支撑这一整合的核心基础设施。
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新产品编号:1232887

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Reduction of 3,4-dimethoxybenzaldehyde (I) with NaBH4 provided benzyl alcohol (II).After conversion of (II) to the benzyl chloride (III) using SOCl2,i...
参考文献标题:Synthesis and antiparasitic and antitumor activity
文献作者:Rosowsky,A.; Papoulis,A.T.; Forsch,R.A.; Queener,S.F.
参考来源:J Med Chem 1999,42(6),1007

新产品编号:1234469

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Reduction of 3,4-dimethoxybenzaldehyde (I) with NaBH4 provided benzyl alcohol (II).After conversion of (II) to the benzyl chloride (III) using SOCl2,i...
参考文献标题:Synthesis and antiparasitic and antitumor activity
文献作者:Rosowsky,A.; Papoulis,A.T.; Forsch,R.A.; Queener,S.F.
参考来源:J Med Chem 1999,42(6),1007

新产品编号:1236051

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Condensation of 4,5-dichloro-1,2-phenylenediamine (I) with 1-phenyl-1,2-propanedione (II) in boiling AcOH provided quinoxaline (III).Subsequent reacti...
参考文献标题:Synthesis of new pyrrolo[1,2-a]quinoxalines: Potential non-peptide glucagon receptor antagonists
文献作者:Guillon,J.; Rault,S.; Kervran,A.; Renard,P.; Manechez,D.; Pfeiffer,B.; Dallemagne,P.
参考来源:Eur J Med Chem 1998,33(4),293

新产品编号:1237633

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:The monoacylation of disulfide (I) with 2-furylcarbonyl chloride (II) by means of 48% HBr in ethanol/water at 80 C gives the monoamide (III),which is ...
参考文献标题:Search for alpha1-adrenoceptor subtypes selective antagonists: Design,synthesis and biological activity of cystazosin,an alpha1D-adrenoceptor antagonist
文献作者:Minarini,A.; Budriesi,R.; Chiarini,A.; Leonardi,A.; Melchiorre,C.
参考来源:Bioorg Med Chem Lett 1998,8(11),1353

新产品编号:1239215

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:N-Boc-D-(3-phenylpropyl)glycine (I) was esterified to benzyl ester (II),and then,tert-butoxycarbonyl group was cleaved by acidic treatment to give ami...
参考文献标题:Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues
文献作者:Barakat,K.J.; Cheng,K.; Chan,W.W.; Butler,B.S.; Jacks,T.M.; Schleim,K.D.; Hora,D.F.Jr.; Hickey,G.J.; Smith,R.G.; Patchett,A.A.; Nargund,R.P.
参考来源:Bioorg Med Chem Lett 1998,8(11),1431

新产品编号:1240797

Chemical Name:
项目整合开发状态: Phase II
项目研究机构:
合成路线:Grignard reagent (II),prepared from 4-chlorobromobenzene (I) and Mg in refluxing THF,was coupled with 1,10-dibromodecane (III) in the presence...
参考文献标题:omega-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
文献作者:Meyer,K.; et al.
参考来源:Eur J Med Chem 1998,33(10),775

新产品编号:1242379

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Friedel Crafts condensation of benzothiophene (I) with p-fluorobenzoyl chloride (II) yielded the benzoyl benzothiophene (III).Then,substitution of the...
参考文献标题:Novel nonsteroidal selective estrogen receptor modulators.Carbon and heteroatom replacement of oxygen in the ethoxypiperidine region of raloxifene
文献作者:Schmid,C.R.; Sluka,J.P.; Duke,K.M.; Glasebrook,A.W.
参考来源:Bioorg Med Chem Lett 1999,9(4),523

新产品编号:1243961

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Thiocolchicine (II) was prepared from colchicine (I) by treatment with sodium methylthiolate.Then,hydrolysis of acetamide group with methanolic HCl af...
参考文献标题:Antitumor agents.185.Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors
文献作者:Guan,J.; Zhu,X.K.; Tachibana,Y.; Bastow,K.F.; Brossi,A.; Hamel,E.; Lee,K.H.
参考来源:J Med Chem 1998,41(11),1956

新产品编号:1245543

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:Grignard reagent (II) was prepared from 3-bromobenzyl halide (I) in Et2O at 0 C,and subsequently added to estrone (III) to provide the target carbinol...
参考文献标题:17alpha-Alkyl- or 17alpha-substituted benzyl-17beta-estradiols: A new family of estrone-sulfatase inhibitors
文献作者:Poirier,D.; Boivin,R.P.
参考来源:Bioorg Med Chem Lett 1998,8(14),1891

新产品编号:1247125

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:The monoacylation of disulfide (I) with 2-furylcarbonyl chloride (II) by means of 48% HBr in ethanol/water at 80 C gives the monoamide (III),which is ...
参考文献标题:Search for alpha1-adrenoceptor subtypes selective antagonists: Design,synthesis and biological activity of cystazosin,an alpha1D-adrenoceptor antagonist
文献作者:Minarini,A.; Budriesi,R.; Chiarini,A.; Leonardi,A.; Melchiorre,C.
参考来源:Bioorg Med Chem Lett 1998,8(11),1353