新产品编号:1247125

Chemical Name:
项目整合开发状态:
项目研究机构:
合成路线:The monoacylation of disulfide (I) with 2-furylcarbonyl chloride (II) by means of 48% HBr in ethanol/water at 80 C gives the monoamide (III),which is then condensed with 2-chloro-6,7-dimethoxyquinazoline-4-amine (IV) in refluxing isoamyl alcohol.

合成路线:Cystamine (I) was acylated with 2-furoyl chloride (II) in the presence of a catalytic amount of HBr to give amide (III).This was then condensed with chloroquinazoline (IV) in refluxing isoamyl alcohol to yield the title compound.