新产品编号:1240797

Chemical Name:
项目整合开发状态: Phase II
项目研究机构:
合成路线:Grignard reagent (II),prepared from 4-chlorobromobenzene (I) and Mg in refluxing THF,was coupled with 1,10-dibromodecane (III) in the presence of Li2CuCl4 as the catalyst to afford the bromodecyl compound (IV).Then,the dianion of dichloroacetic acid (V),generated in the presence of two equivalents of LDA in cold THF,was alkylated with bromide (IV) to provide the title compound.