项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

新产品编号:326401

2-(5-氯-2-羟基苯基)-5-[4-(三氟甲基)苯基]-3,4-二氢-2H-1,2,4-三唑-3-1Chemical Name: 2-(5-Chloro-2-hydroxyphenyl)-5-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
CAS No. 202822-21-7
项目整合开发状态: Bio...
参考文献标题:Diphenyl oxadiazolones as potassium channel modulators
文献作者:Meanwell,N.A.; Starrett,J.E.Jr.; Hewawasam,P.; Romine,J.L.; Martin,S.W.; Gribkoff,V.K.(Bristol-Myers Squibb Co.)
参考来源:JP 2000516925; US 5869509; WO 9804135

Cadralazine, CGP-18684/E, ISF-2469, Cadrilan, Cadraten

2-(6-(乙基(2-羟丙基)氨基)哒嗪-3-基)肼甲酸乙酯Chemical Name: 3-[6-[Ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]carbazic acid ethyl ester
CAS No. 64241-34-5
项目整合开发状态: Launched-1988
项目研究机构: Dainippon Pharmaceut...
参考文献标题:6-Substituted 3-carbethoxyhydrazinopyridazines
文献作者:Carpi,C.; Dorigotti,L.; Pifferi,G.(ISF SpA)
参考来源:US 4002753

4,5-Dibromorhodamine 123, TH-9402

2-(6-氨基-4,5-二溴-3-亚胺基-3H-黄酮-9-基)苯甲酸甲酯盐酸Chemical Name: 2-(6-Amino-4,5-dibromo-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester hydrochloride
CAS No. 174230-05-8
项目整合开发状态: Phase I/II
项目研究机构: Ce...
参考文献标题:Phototoxicity of some bromine-substituted rhodamine dyes: Synthesis,photophysical properties and application as photosensitizers
文献作者:Pal,P.; Zeng,H.Y.; Durocher,G.; Girard,D.; Li,T.; Gupta,A.K.; Giasson,R.; Blanchard,L.; Gaboury,L.; Balassy,A.; Turmel,C.; Laperriere,A.; Villeneuve,L.
参考来源:Photochem Photobiol 1996,63(2),161

NM-3

2-(8-羟基-6-甲氧基-1-氧代异苯并吡喃-3-基)丙酸Chemical Name: 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid
CAS No. 181427-78-1
项目整合开发状态: Phase I/II
项目研究机构: Mercian (Supplier), Ilex Oncolog...
参考文献标题:Isocoumarin derivs.and use thereof in drugs
文献作者:Hirano,S.; Mase,T.; Agata,N.; Iguchi,H.; Matsumoto,N.; Yoshioka,T.; Tone,H.; Kumagai,H.; Ishizuka,M.; Tkeuchi,T.(Mercian Corp.)
参考来源:EP 0930310; US 6020363; WO 9748693

FPL-66564

2(R)-[3-巯基-2(S)-甲基丙基桥氧基]-3-(甲硫基)丙酸Chemical Name: 2(R)-[3-Mercapto-2(S)-methylpropanoyloxy]-3-(methylthio)propanoic acid
CAS No. 140369-78-4
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (Originat...
参考文献标题:Angiotensin converting enzyme inhibitors
文献作者:Baxter,A.J.G.; Meghani,P.(Celltech Medeva plc)
参考来源:EP 0535496; JP 1993507919; US 5348978; WO 9200276

ABS-103R, R-ABS-103, R-103

2(R)-丙基-4-己糖酸Chemical Name: 2(R)-Propyl-4-hexynoic acid
CAS No. 155899-34-6
项目整合开发状态: Preclinical
项目研究机构: American Biogenetic Sciences (Originator)
合成路线:The alkylation of diethyl n-propylm...
参考文献标题:VPA-analogous antiepileptics
文献作者:Hauck,R.-S.; Elmazar,M.M.E.; Nau,H.; Bojic,U.
参考来源:DE 4231085; US 5786380; WO 9406743

SB-201076

2(R*)-[8-(2,4-二氯苯基)-2(S*)-羟基辛基]-2-羟基丁二酸Chemical Name: 2(R*)-[8-(2,4-dichlorophenyl)-2(S*)-hydroxyoctyl]-2-hydroxybutanedioic acid
CAS No. 154566-05-9
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithK...
参考文献标题:ATP-citrate lyase as a target for hypolipidemic intervention.2.Synthesis and evaluation of (3R*,5S*)-omega-substituted-3-carboxy-3,5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo
文献作者:Gribble,A.D.; Ife,R.J.; Shaw,A.; McNair,D.; Novelli,C.E.; Bakewell,S.; Shah,V.P.; Dolle,R.E.; Groot,P.H.; Pearce,N.; Yates,J.; Tew,D.; Boyd,H.; Ashman,S.; Eggleston,D.S.; Haltiwanger,R.C.; Okafo,G.
参考来源:J Med Chem 1998,41(19),3582

Eflucimibe, F-12511

2(S)-(十二基磺酰)-N-(4-羟基-2,3,5-三甲基苯基)-2-苯乙酰胺Chemical Name: 2(S)-(Dodecylsulfanyl)-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-phenylacetamide
CAS No. 202340-45-2, 191791-65-8 (undefined isomer)
项目整合开发状态: ...
参考文献标题:Novel 2,3,5-trimethyl-4-hydroxy anilide derivs.,preparation thereof
文献作者:Patoiseau,J.-F.; Autin,J.-M.; Delhon,A.; Oms,P.; Junquero,D.(Pierre Fabre M閐icament)
参考来源:EP 0874812; FR 2741619; JP 2000500771; US 5990173; WO 9719918

Aplindore fumarate, Palindore fumarate, WAY-135452, DAB-452, WAY-DAB-452

2(S)-(苄氨甲基)-2,3,8,9-四氢-7H-1,4-二氧化铚[2,3-e]鐲哚-8-1-一呋喃酸盐 (2S)-2-[(苄氨基)甲基]-2,3,7,9-四氢-8H-[1,4]二氧銲[2,3-e]吲哚-8-酮 Chemical Name: 2(S)-(Benzylaminomethyl)-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-one f...
参考文献标题:Dioxino derivs.and their use as dopamine agonists
文献作者:Stack,G.P.; Mewshaw,R.E.; Bravo,B.A.; Kang,Y.H.(Wyeth)
参考来源:EP 0771800; JP 1997249671; US 5756532

L-750034

2(S)-(苯磺酰氨基)-3-[4-(1-哌嗪基)苯甲酰氨基]丙酸Chemical Name: 2(S)-(Phenylsulfonamido)-3-[4-(1-piperazinyl)benzamido]propionic acid
CAS No. 163209-37-8
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator...
参考文献标题:Fibrinogen receptor antagonists
文献作者:Egbertson,M.S.; Turchi,L.M.; Hartman,G.D.; Halczenko,W.; Whitman,D.B.; Perkins,J.J.; Krause,A.E.; Ihle,N.; Claremon,D.A.; Hoffman,W.; Duggan,M.E.(Merck & Co.,Inc.)
参考来源:EP 0673247; JP 1996504194; WO 9412181