4,5-Dibromorhodamine 123, TH-9402
2-(6-氨基-4,5-二溴-3-亚胺基-3H-黄酮-9-基)苯甲酸甲酯盐酸Chemical Name: 2-(6-Amino-4,5-dibromo-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester hydrochloride
CAS No. 174230-05-8
项目整合开发状态: Phase I/II
项目研究机构: Celmed BioSciences (Orphan Drug), Celmed BioSciences (Originator), Theratechnologies (Originator)
合成路线:Fischer esterification of rhodamine (I) with methanolic HCl affords the corresponding methyl ester (II).Subsequent bromination of (II) with a solution of Br2 in ethanol yields the title compound.
📌 参考资料/链接：
参考文献标题:Phototoxicity of some bromine-substituted rhodamine dyes: Synthesis,photophysical properties and application as photosensitizers
文献作者:Pal,P.; Zeng,H.Y.; Durocher,G.; Girard,D.; Li,T.; Gupta,A.K.; Giasson,R.; Blanchard,L.; Gaboury,L.; Balassy,A.; Turmel,C.; Laperriere,A.; Villeneuve,L.
参考来源:Photochem Photobiol 1996,63(2),161