Eflucimibe, F-12511
2(S)-(十二基磺酰)-N-(4-羟基-2,3,5-三甲基苯基)-2-苯乙酰胺Chemical Name: 2(S)-(Dodecylsulfanyl)-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-phenylacetamide
CAS No. 202340-45-2, 191791-65-8 (undefined isomer)
项目整合开发状态: Phase II
项目研究机构: Pierre Fabre (Originator), Lilly (Licensee)
合成路线:The title amide was synthesized by coupling 2,3,6-trimethyl-4-aminophenol hydrochloride (I) with (+)-alpha-dodecylthio-alpha-phenylacetic acid (II) in the presence of dicyclohexylcarbodiimide and triethylamine.
📌 参考资料/链接：
参考文献标题:Novel 2,3,5-trimethyl-4-hydroxy anilide derivs.,preparation thereof
文献作者:Patoiseau,J.-F.; Autin,J.-M.; Delhon,A.; Oms,P.; Junquero,D.(Pierre Fabre M閐icament)
参考来源:EP 0874812; FR 2741619; JP 2000500771; US 5990173; WO 9719918