项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Sercloremine hydrochloride, CGP-4718A

Chemical Name: 4,5-(Chloro-2-benzofuranyl)-1-methylpiperidine hydrochloride; 5-Chloro-2-(1-methyl-4-piperidyl)benzofuran hydrochloride
CAS No. 54403-20-2, 54403-19-9 (free base)
项目整合开发状态: Phase ...
参考文献标题:Anti-depressant benzofuranyl piperidines
文献作者:Bernasconi,R.; Schenker,K.(Novartis Corp.)
参考来源:CH 592656; CH 605926; DE 2408476; FR 2219781; JP 49117474; JP 58004781; US 210655

Cromakalim, M&B-44809, BRL-38227((-)-enantiomer), BRL-38266((+)-enantiomer), BRL-34915

Chemical Name: (?-trans-6-Cyano-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-benzo[b]pyran-3-ol
CAS No. 94470-67-4, 86776-67-2 (undefined stereoch.)
项目整合开发状态: Phase III
项目研究机构: GlaxoS...
参考文献标题:Antihypertensive chromenes and chromans
文献作者:Faruk,E.A.(SmithKline Beecham plc)
参考来源:EP 0093535; US 4510152

DuP-923(diHCl), ACC-9358

Chemical Name: 2,6-Bis(N-pyrrolidinomethyl)-4-(phenylcarbamyl)phenol
CAS No. 90446-66-5
项目整合开发状态: Phase II
项目研究机构: American Hospital Supply (Originator), Bristol-Myers Squibb (Originator)
...
参考文献标题:ACC-9358
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1986,11(3),169

M-12285

Chemical Name: 6-Chloro-4-oxyimino-1-propionyl-1,2,3,4-tetrahydroquinoline; 6-Chloro-1-ethylcarbonyl-4-oxyimino-1,2,3,4-tetrahydroquinoline
CAS No. 81075-14-1
项目整合开发状态: Preclinical
项目研究机构: Mo...
参考文献标题:M-12,285
文献作者:Hillier,K.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(3),204

Ly-134046

Chemical Name: 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride
CAS No. 69739-51-1, 71274-97-0 (free base)
项目整合开发状态: Not Determined
项目研究机构: Lilly (Originator)
合成路线:The conden...
参考文献标题:LY-134046
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(4),268

Viprostol, CL-115347

Chemical Name: 15-Deoxy-16-hydroxy-16-vinylprostaglandin E2 methyl ester; Methyl 9-oxo-11alpha,16-dihydroxy-16-vinyl-5-cis,13-trans-prostadienoate; (5Z,11alpha,13E)-16-Ethenyl-11,16-dihydroxy-9-oxo-pr...
参考文献标题:Novel prostaglandin compounds
文献作者:Middlenton,B.F.; Martin,J.W.; Grudzinskas,C.V.; Chen,S.L.(American Cyanamid Co.)
参考来源:ES 475787; FR 2410648; GB 2009173; US 4198521

ID-1229

Chemical Name: 2-[3-(4-Fluorobenzoyl)-1-propyl]-5alpha,9alpha-dimethyl-2'-hydroxy-6,7-benzomorphan; 3-[3-(4-Fluorobenzoyl)-1-propyl]-1,2,3,4,5,6-hexahydro-8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazo...
参考文献标题:Novel benzomorphan and their salts as analgesics
文献作者:Atsumi,T.; et al.(Sumitomo Chemical Co.,Ltd.)
参考来源:US 3873706

B-77781

Chemical Name: 4-(4-Aminophenoxy)-1-methyl-4-phenylpiperidine; 4-[(1-Methyl-4-phenyl-4-piperidinyl)oxy]benzeneamine
CAS No. 78104-11-7
项目整合开发状态: Biological Testing
项目研究机构: Altana Pharma (Orig...
参考文献标题:Anti-depressant and analgesic 4-phenoxypiperidines
文献作者:Eistetter,K.; Kley,H.-P.; Menge,H.G.; Schaefer,H.(Byk Gulden Lomberg Chemische Fabrik GmbH)
参考来源:US 4333942

Metahexestrol, NSC-297170, 3,3'-HES

Chemical Name: 3,3'-Hexestrol; meso-3,4-Bis(3'-hydroxyphenyl)hexane; meso-3,3'-(1,2-Diethylethylene)diphenol
CAS No. 71953-72-5
项目整合开发状态: Preclinical
项目研究机构: Universit鋞 Regensburg (Originator...
参考文献标题:Novel di-(3'-hydroxyphenyl)-alkane cpds.,process of preparation and their use in medicine
文献作者:Sch鰊enberger,H.; Kranfelder,G.; Schmitt-Wallenborn,H.(Klinge Pharma GmbH)
参考来源:DE 2658307; US 4094994

BW-245C

Chemical Name: (?-5-(6-Carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin; (?-3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-4-imidazolidineheptanoic acid
CAS No. 72814-36-9 ((R*,R*)-isomer), 7281...
参考文献标题:BW-245-C
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1982,7(6),380