M-12285
Chemical Name: 6-Chloro-4-oxyimino-1-propionyl-1,2,3,4-tetrahydroquinoline; 6-Chloro-1-ethylcarbonyl-4-oxyimino-1,2,3,4-tetrahydroquinoline
CAS No. 81075-14-1
项目整合开发状态: Preclinical
项目研究机构: Mochida (Originator)
合成路线:The reaction of 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline (I) with propionic anhydride (II) or propionyl chloride (III) in pyridine gives 6-chloro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (IV),which is then treated with hydroxylamine hydrochloride in refluxing pyridine.
📌 参考资料/链接：
参考文献标题:M-12,285
文献作者:Hillier,K.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(3),204
📄 详细内容
合成路线:The reaction of 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline (I) with propionic anhydride (II) or propionyl chloride (III) in pyridine gives 6-chloro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (IV),which is then treated with hydroxylamine hydrochloride in refluxing pyridine.
参考文献标题:Hypotensive diuretic pharmaceutical compositions containing tetrahydroquinoline derivatives
文献作者:Suzuki,Y.; Ohnishi,H.; Yamaguchi,K.; Mochida,E.; Kosuzume,H.
参考来源:DE 3129719; FR 2487196; GB 2081091
合成路线:The reaction of 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline (I) with propionic anhydride (II) or propionyl chloride (III) in pyridine gives 6-chloro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (IV),which is then treated with hydroxylamine hydrochloride in refluxing pyridine.
参考文献标题:4-Oximino-1,2,3,4- tetrahydroquinoline Derivatives
文献作者:Susumi,J.; Shoichi,K.; Koichi,K.
参考来源:DE 3129718; FR 2487346; GB 2092130
合成路线:The reaction of 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline (I) with propionic anhydride (II) or propionyl chloride (III) in pyridine gives 6-chloro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (IV),which is then treated with hydroxylamine hydrochloride in refluxing pyridine.
参考文献标题:Pharmacological properties of 6-chloro-1-ethylcarbonyl-4-oxyimino-1,2,3,4-tetrahydroquinoline
文献作者:Suzuki,Y.; Yamaguchi,K.; Ohnishi,H.; Takada,K.; Toyonaka,Y.; Orita,Y.
参考来源:Drugs Exp Clin Res 1981,7(6),823-832