B-77781
Chemical Name: 4-(4-Aminophenoxy)-1-methyl-4-phenylpiperidine; 4-[(1-Methyl-4-phenyl-4-piperidinyl)oxy]benzeneamine
CAS No. 78104-11-7
项目整合开发状态: Biological Testing
项目研究机构: Altana Pharma (Originator)
合成路线:Reaction of 1-methyl-4-piperidone (I) with phenyllithium (II) gives 1-methyl-4-phenyl-4-piperidinol (III),which is alkylated with (IV) in NaH/DMF to yield (V),followed by reduction with hydrazine/Raney-Ni.
📌 参考资料/链接：
参考文献标题:Anti-depressant and analgesic 4-phenoxypiperidines
文献作者:Eistetter,K.; Kley,H.-P.; Menge,H.G.; Schaefer,H.(Byk Gulden Lomberg Chemische Fabrik GmbH)
参考来源:US 4333942
📄 详细内容
合成路线:Reaction of 1-methyl-4-piperidone (I) with phenyllithium (II) gives 1-methyl-4-phenyl-4-piperidinol (III),which is alkylated with (IV) in NaH/DMF to yield (V),followed by reduction with hydrazine/Raney-Ni.
参考文献标题:B-777-81
文献作者:Menge,H.G.; Eistetter,K.; Schaefer,H.; Kley,H.-P.
参考来源:Drugs Fut 1983,8(5),387
产品链接: CAS No. 78104-11-7››