DuP-923(diHCl), ACC-9358
Chemical Name: 2,6-Bis(N-pyrrolidinomethyl)-4-(phenylcarbamyl)phenol
CAS No. 90446-66-5
项目整合开发状态: Phase II
项目研究机构: American Hospital Supply (Originator), Bristol-Myers Squibb (Originator)
合成路线:The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III),which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:ACC-9358
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1986,11(3),169
📄 详细内容
合成路线:The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III),which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.
参考文献标题:Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols.3.Modifications to the linkage region (Region 3(
文献作者:Stout,D.M.; Matier,W.L.; Barcelon-Yang,C.; Reynolds,R.D.; Brown,B.S.
参考来源:J Med Chem 1985,28(3),295-298
产品链接: CAS No. 90446-66-5››