项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

LFA-451

Chemical Name: 2(S)-Methylbutyric acid (1S,3R,7S,8S,8aR)-8-[2-[(4R,6R)-4-[N-(2-hydroxyethyl)carbamoylmethyl]-3-(4-hydroxy-3-methoxybenzyl)-2-oxoperhydro-1,3-oxazin-6-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8...
参考文献标题:Mevinolin derivs.
文献作者:Hommel,U.; Bauer,W.; Meingassner,J.G.; Weitz-Schmidt,G.; Ehrhardt,C.; Kallen,J.; Banteli,R.; Cottens,S.; Nuninger,F.(Novartis AG; Novartis-Erfindungen VmbH)
参考来源:EP 1154988; WO 0048989

新产品编号:734557

Chemical Name: 3-[3-(3-Acetylphenyl)ureido]-2-[4-(4-fluorobenzyl)piperidin-1-ylmethyl]-N-methylbenzamide
CAS No. 275811-34-2, 275811-45-5 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Bristol...
参考文献标题:N-Ureidoalkyl-piperidines as modulators of chemokine receptor activity
文献作者:Ko,S.S.; Santella,J.B.III; Wacker,D.A.; Kim,U.T.; Duncia,J.V.K.(Bristol-Myers Squibb Co.)
参考来源:EP 1140087; US 6492400; WO 0035454

VER-5593

Chemical Name: 1-[5-Fluoro-6-methylsulfanyl-2,3-dihydro-1H-indol-1-yl]propan-2(S)-amine
CAS No. 259858-34-9, 259858-35-0 (fumarate salt), 259859-03-5 (undefined isomer)
项目整合开发状态: Preclinical
...
参考文献标题:Indoline derivs.as 5-HT2B and/or 5-HT2C receptor ligands
文献作者:Bebbington,D.; Gaur,S.; Adams,D.R.; Monck,N.J.; Bentley,J.M.; Hamlyn,R.J.; Duncton,M.A.J.; Dawson,C.E.; Pratt,R.M.; George,A.R.; Roffey,J.R.A.(Vernalis Research Ltd.)
参考来源:EP 1109784; JP 2002523491; US 6380238; WO 0012475

A-331440, ABBOTT-331440

Chemical Name: 4'-[3-[3(R)-(Dimethylamino)pyrrolidin-1-yl]propoxy]biphenyl-4-carbonitrile
CAS No. 392338-13-5
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:The title compound is p...
参考文献标题:1,3-Disubstd.and 1,3,3-trisubstd.pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
文献作者:Faghih,R.; Bennani,Y.L.; Dwight,W.J.; Vasudevan,A.; Conner,S.E.(Abbott Laboratories Inc.)
参考来源:WO 0206223

新产品编号:922815

Chemical Name: N-(4-Bromobenzylsulfonyl)-D-seryl-N1-(4-guanidinobenzyl)-L-alaninamide
CAS No. 400721-44-0
项目整合开发状态: Biological Testing
项目研究机构: Corvas (Originator)
合成路线:4-Nitrobenzylamine (...
参考文献标题:Non-covalent inhibitors of urokinase and blood vessel formation
文献作者:Semple,J.E.; Levy,O.E.; Tamiz,A.P.; Madison,E.L.; Weinhouse,M.I.(Corvas International,Inc.)
参考来源:EP 1182207; WO 0214349

新产品编号:897503

Chemical Name: N-[2-[2-Chloro-6-(beta-D-galactopyranosyloxy)-1,2,3,4-tetrahydrobenzo[f]quinolin-4-ylcarbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide
CAS No. 371155-19-0
项目整合开发状态: Preclinical
...
参考文献标题:Novel prodrugs of 6-hydroxy-2,3-dihydro-1H-indoles,5-hydroxy-1,2-dihydro-3H-pyrrolo[3,2-e]indoles and 5-hydroxy-1,2-dihydro-3H-benzo[e]indoles as well as of 6-hydroxy-1,2,3,4-tetrahydro-benzo[f]quinoline derivs.for use in selective cancer therapy
文献作者:Tietze,L.F.; Fecher,A.; Herzig,T.
参考来源:WO 0183448

新产品编号:943381

Chemical Name: 3-[4-[2-[4-[3-(2-Methylphenyl)ureido]phenyl]acetamido]phenyl]butyric acid
CAS No. 446069-87-0
项目整合开发状态: Preclinical
项目研究机构: Biogen Idec (Originator)
合成路线:Reduction of methyl...
参考文献标题:Identification of potent and novel alpha4beta1 antagonists using in silico screening
文献作者:Singh,J.; van Vlijmen,H.; Liao,Y.; Lee,W.-C.; Cornebise,M.; Harris,M.; Shu,I.-h.; Gill,A.; Cuervo,J.H.; Abraham,W.M.; Adams,S.P.
参考来源:J Med Chem 2002,45(14),2988

Org-25415, TAAC3

Chemical Name: trans,trans-Pentanedioic acid bis[8-(3,4-diacetoxybenzyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] diester dibromide
CAS No. 223920-46-5
项目整合开发状态: Preclinical
项目研究机构: Organon...
参考文献标题:Neuromuscular relaxants
文献作者:Lee,C.; Gyermek,L.; Cho,Y.-M.
参考来源:JP 2001521032; US 5990124; WO 9921854

SMP-500

Chemical Name: N-[1-Butyl-2-oxo-4-[3-(pyridin-3-ylmethoxy)phenyl]-1,2-dihydro-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea nitrate
CAS No. 208166-87-4 (free base)
项目整合开发状态: Preclinical<...
参考文献标题:Novel naphthyridine derivs.
文献作者:Muraoka,M.; Ioriya,K.; Ohashi,N.; Yagi,H.(Sumitomo Pharmaceuticals Co.,Ltd.)
参考来源:EP 0947515; JP 1998212288; WO 9823615

新产品编号:422903

Chemical Name: 6-Amino-2-[3-(cyclopentyloxy)-4-methoxyphenyl]isoindolin-1-one
CAS No. 214071-20-2
项目整合开发状态: Biological Testing
项目研究机构: Daewoong (Originator)
合成路线:Alkylation of 2-methoxy-5-...
参考文献标题:Synthesis and SAR studies for the inhibition of TNF-alpha production.Part 2.2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-substituted-1-isoindolinone derivatives
文献作者:Park,J.S.; Moon,S.C.; Baik,K.U.; Cho,J.Y.; Yoo,E.S.; Byun,Y.S.; Park,M.H.
参考来源:Arch Pharmacal Res 2002,25(2),137