A-331440, ABBOTT-331440
Chemical Name: 4'-[3-[3(R)-(Dimethylamino)pyrrolidin-1-yl]propoxy]biphenyl-4-carbonitrile
CAS No. 392338-13-5
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.
📌 参考资料/链接：
参考文献标题:1,3-Disubstd.and 1,3,3-trisubstd.pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
文献作者:Faghih,R.; Bennani,Y.L.; Dwight,W.J.; Vasudevan,A.; Conner,S.E.(Abbott Laboratories Inc.)
参考来源:WO 0206223
📄 详细内容
合成路线:The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.
参考文献标题:1,3-Disubstd.and 1,3,3-trisubstd.pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
文献作者:Faghih,R.; Bennani,Y.L.; Dwight,W.J.; Vasudevan,A.; Conner,S.E.(Abbott Laboratories Inc.)
参考来源:US 2002035103; US 6515013
产品链接: CAS No. 392338-13-5››