新产品编号:734557

Chemical Name: 3-[3-(3-Acetylphenyl)ureido]-2-[4-(4-fluorobenzyl)piperidin-1-ylmethyl]-N-methylbenzamide
CAS No. 275811-34-2, 275811-45-5 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Condensation of 2-(bromomethyl)-N-methyl-3-nitrobenzamide (I) with 4-(4-fluorobenzyl)piperidine (II) affords the piperidinylmethyl benzamide (III).The nitro group of (III) is then reduced by catalytic hydrogenation over Pd/C to provide aniline (IV).Subsequent coupling of aniline (IV) with 3-acetylphenyl isocyanate (V) leads to the target N,N'-diaryl urea.