Org-25415, TAAC3
Chemical Name: trans,trans-Pentanedioic acid bis[8-(3,4-diacetoxybenzyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] diester dibromide
CAS No. 223920-46-5
项目整合开发状态: Preclinical
项目研究机构: Organon (Originator)
合成路线:Acylation of tropine (I) with glutaryl chloride (II) furnishes bis(tropan-3-yl) glutarate (III).Subsequent quaternization of (III) with 3,4-diacetoxybenzyl bromide (IV) in refluxing acetone yields the corresponding bis-ammonium sal.
📌 参考资料/链接：
参考文献标题:Neuromuscular relaxants
文献作者:Lee,C.; Gyermek,L.; Cho,Y.-M.
参考来源:JP 2001521032; US 5990124; WO 9921854
📄 详细内容
合成路线:Acylation of tropine (I) with glutaryl chloride (II) furnishes bis(tropan-3-yl) glutarate (III).Subsequent quaternization of (III) with 3,4-diacetoxybenzyl bromide (IV) in refluxing acetone yields the corresponding bis-ammonium sal.
参考文献标题:Neuromuscular relaxants
文献作者:Lee,C.; Gyermek,L.; Cho,Y.-M.(Newlaxant LLC)
参考来源:US 6376510