项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

DP-109

Chemical Name: 2,2'-(Ethylenedioxy)bis(1,2-phenylene)bis[N-[2-[2-(octadecyloxy)ethoxy]-2-oxoethyl]imino]bis(acetic acid)
CAS No. 347841-31-0
项目整合开发状态: Preclinical
项目研究机构: D-Pharm (Originator)...
参考文献标题:Lipophilic diesters of chelating agents
文献作者:Kozak,A.; Shapiro,I.(D-Pharm Ltd.)
参考来源:JP 2001518458; WO 9916741

UTA-6026

Chemical Name: 4-[(11aS)-7-Methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy]-N-[2-[(7bR,8aS)-7-methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indol-2-ylcar...
参考文献标题:Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent
文献作者:Zhou,Q.; Duan,W.; Simmons,D.; Shayo,Y.; Raymond,M.A.; Dorr,R.T.; Hurley,L.H.
参考来源:J Am Chem Soc 2001,123(20),4865

GT-015, GT-715

Chemical Name: 3,3'-Disulfanylbis-1,2-propanediol tetranitrate
CAS No. 179677-60-2
项目整合开发状态: Preclinical
项目研究机构: GBtherapeutics (Originator), Queen's University (Originator)
合成路线:The nitra...
参考文献标题:Nitrate esters and their use for neurological conditions
文献作者:Bennett,B.M.; Boegman,R.J.; Jhamandas,K.; Thatcher,G.R.; Reynolds,J.N.(Queen's University)
参考来源:US 5807847; WO 9746521

PRS-211095

Chemical Name: (6aS,10aS)-3-(1,1-Dimethylheptyl)-9-(1H-imidazol-1-ylmethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-1-ol hydrochloride
CAS No. 382137-87-3, 374110-39-1 (free base)<...
参考文献标题:Novel non-psychotropic cannabinoids
文献作者:Fink,G.; Garzon,A.(Pharmos Corp.)
参考来源:WO 0198289

IST-FS-29

Chemical Name: (1R,9aR)-1-(Triethylstannylsulfanylmethyl)perhydroquinolizine hydrochloride
CAS No. 218948-55-1, 233673-07-9 (free base)
项目整合开发状态: Preclinical
项目研究机构: Istituto Nazionale Ricerc...
参考文献标题:Triorganotin compounds as antimicrobial agents
文献作者:Novelli,F.; Recine,M.; Sparatore,F.; Juliano,C.
参考来源:Farmaco 1999,54(4),237

KMUP-1

Chemical Name: 7-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 7-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]-1,3-dimethylxanthine; 7-[2-[4-(2-Chlorophenyl)p...
参考文献标题:Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivs.as active ingredient
文献作者:Kaneko,T.; Sugimoto,H.; Ozaki,S.; Takizawa,K.(Eisai Co.,Ltd.)
参考来源:DE 3307395; EP 0087810; US 4543254

新产品编号:748795

Chemical Name: 3-[3,17beta-Dihydroxyestra-1(10),2,4-trien-17-yl]-2-propynoic acid cyclodec-5-en-3,7-diyn-1-ylmethyl ester
CAS No. 286428-06-6
项目整合开发状态: Biological Testing
项目研究机构: Beth Israel ...
参考文献标题:Target-directed enediynes: Design estramycins
文献作者:Jones,G.B.; Hynd,G.; Wright,J.M.; Purohit,A.; Plourde,G.W.II.; Huber,R.S.; Mathews,J.E.; Li,A.; Kilgore,M.W.; Bubley,G.J.; Yancisin,M.; Brown,M.A.
参考来源:J Org Chem 2001,66(11),3688

L-294, LASSBio-294

Chemical Name: (E)-N'-(Thien-2-ylmethylene)-1,3-benzodioxole-5-carbohydrazide
CAS No. 314021-07-3
项目整合开发状态: Preclinical
项目研究机构: LASSBio (Originator), University of Maryland (Originator)
合成...
参考文献标题:Thienylhydrazon with digitalis-like properties (positive inotropic effects)
文献作者:Sudo,R.T.; Alburquerque,E.X.; De Barreiro,E.J.(University of Maryland)
参考来源:WO 0078754

RPR-119990

Chemical Name: 2-(4-Oxo-2-phosphono-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-9-yl)acetic acid hydrochloride
CAS No. 183734-91-0, 294841-69-3 (free base)
项目整合开发状态: Preclinical
项目研究机构...
参考文献标题:5H-10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one derivs.,preparation thereof,and drugs containing said derivs.
文献作者:Aloup,J.-C.; Hardy,J.-C.; Mignani,S.; Jimonet,P.; Audiau,F.; Barreau,M.; Manfre,F.; Damour,D.; Ribeill,Y.; Genevois-Borella,A.; Nemecek,P.(Aventis Pharma SA)
参考来源:WO 9631511

T-1172

Chemical Name: N-[1-(2-Fluorophenyl)-6-methoxy-3(S)-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-9H-beta-carboline-3-carboxamide methanesulfonate; N-[1-(2-Fluorophenyl)-6-methoxy-3(S)-methyl-2-oxo-2,3-dihy...
参考文献标题:Beta-carboline derivs.with anticholecystoquinine activity
文献作者:Yamada,K.; Hikota,M.; Yura,T.; Shikano,T.; Nagasaki,M.(Tanabe Seiyaku Co.,Ltd.)
参考来源:EP 0572235; JP 1994041126; US 5434148