PRS-211095

Chemical Name: (6aS,10aS)-3-(1,1-Dimethylheptyl)-9-(1H-imidazol-1-ylmethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-1-ol hydrochloride
CAS No. 382137-87-3, 374110-39-1 (free base)
项目整合开发状态: Preclinical
项目研究机构: Pharmos (Originator)
合成路线:The reductive cyclization of dimethyl 4-nitropimelate (I) with H2 over Pd/C in methanol gives 3-(2-oxo-5-pyrrolidinyl)propanoic acid (II),which is then treated with hot acetic anhydride.

合成路线:Dexanabinol (I) was brominated using carbon tetrabromide in the presence of triphenylphosphine.The resultant allylic bromide (II) was then condensed with the lithium salt of imidazole (III) to produce the title compound.