DP-109

Chemical Name: 2,2'-(Ethylenedioxy)bis(1,2-phenylene)bis[N-[2-[2-(octadecyloxy)ethoxy]-2-oxoethyl]imino]bis(acetic acid)
CAS No. 347841-31-0
项目整合开发状态: Preclinical
项目研究机构: D-Pharm (Originator)
合成路线:By condensation of 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine (I) with 3,4-methylenedioxyphenol (II) with dicyclohexylcarbodiimide (DCC) at 180 C.

合成路线:Treatment of 1,2-bis-(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride and pyridine provided the cyclic anhydride (II).Ethylene glycol octyl ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (III) and n-octyl bromide (IV).Finally,the title diester was obtained by heating anhydride (II) with the octyl ether of ethyleneglycol (V).

合成路线:Treatment of bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride in hot pyridine produced the cyclic anhydride (II).Ethyleneglycol mono-ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (IV) and octadecyl bromide (III).Then,heating the bis-anhydride (II) with ethyleneglycol monoether (V) produced the title diester