项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:308999

Chemical Name: N-[4-[2-[2(R)-Hydroxy-2-(3-pyridyl)ethylamino]ethyl]phenyl]-4-[5-[4-(trifluoromethoxy)benzyl]-1,2,4-oxadiazol-3-yl]benzenesulfonamide
CAS No. 200510-30-1, 200504-84-3 (trifluoroaceta...
参考文献标题:Oxadiazole benzenesulfonamides as selective beta3 agonists for the treatment of diabetes and obesity
文献作者:Biftu,T.; Feng,D.D.; Fisher,M.H.; Kuo,C.-H.; Liang,G.-B.; Weber,A.E.; Naylor,E.M.(Merck & Co.,Inc.)
参考来源:EP 0906310; US 6034106; WO 9746556

新产品编号:179275

Chemical Name: 3-(3-Carboxybenzyl)-1-(6-ethyl-1,3-benzodioxol-5-ylmethyl)-4-oxo-1,4-dihydroquinoline-2-carboxylic acid dipotassium salt
CAS No. 184242-30-6
项目整合开发状态: Preclinical
项目研究机构: Avent...
参考文献标题:Quinoline derivs.,process for their preparation,the resultant intermediates,their use as medicaments and the pharmaceutical compsns.containing them
文献作者:Haesslein,J.-L.(Aventis Pharma SA)
参考来源:FR 2733233; WO 9633190

SNAP-7915

Chemical Name: (+)-4(S)-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5(S)-methyl-2-oxooxazolidine-3-carboxamide
CAS No. 218450-16-9, 218450-17-0 (racemic, HCl)
项目整合开发状态: P...
参考文献标题:Heterocyclic substd.piperidines and uses thereof
文献作者:Marzabadi,M.R.; Wong,W.C.; Gluchowski,C.; Tian,D.; Nagarathnam,D.; Lagu,B.; Dhar,T.G.M.; Jeon,Y.T.(Synaptic Pharmaceutical Corp.)
参考来源:EP 0988295; WO 9857940

2-Benzylthio-ATPalphaS

Chemical Name: 2-Benzylsulfanyl-5'-O-(1-thiotriphosphate)adenosine
CAS No. 246150-03-8 (R-isomer), 246150-04-9 (S-isomer), 246150-02-7 (undefined isomer)
项目整合开发状态: Biological Testing
项目研究机构: ...
参考文献标题:2-Thiother 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-receptors
文献作者:Fischer,B.; Chulkin,A.; Boyer,J.L.; Harden,K.T.; Gendron,F.P.; Beaudoin,A.R.; Chapal,J.; Hillaire-Buys,D.; Petit,P.
参考来源:J Med Chem 1999,42(18),3636

NO-Mesalamine, NO-5-ASA, NCX-456

Chemical Name: 5-Amino-2-hydroxybenzoic acid 4-(nitrooxy)butyl ester
CAS No. 256499-26-0
项目整合开发状态: Preclinical
项目研究机构: NicOx (Originator)
合成路线:5-Amino-2-hydroxybenzoic acid (I) was protect...
参考文献标题:Medicine nitrate salts
文献作者:Del Soldato,P.(NicOx SA)
参考来源:WO 0006585

Neomycin B-arginine conjugate, Neomycin B-hexaarginine conjugate, NeoR6, NeoR

Chemical Name: N1,N3-Bis(L-arginyl)-O-2,6-bis(L-arginylamino)-2,6-dideoxy-alpha-D-glucopyranosyl-(1--4)-[O-2,6-bis(L-arginylamino)-2,6-dideoxy-beta-L-idopyranosyl-(1--3)-beta-D-ribofuranosyl-(1--5)]-2...
参考文献标题:Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino cpds.
文献作者:Lapidot,A.; Litovchick,A.; Evdokimov,A.(Yeda Research & Development Co.Ltd.)
参考来源:WO 0039139

Denufosol tetrasodium, dCp4U, INS-37217

Chemical Name: P1-(2'-Deoxycytidin-5'-yl)-P4-(uridin-5'-yl)tetraphosphate tetrasodium salt; Uridine 5'-(pentahydrogen tetraphosphate) P'''--5'-ester with 2'-deoxycytidine tetrasodium salt
CAS No. 3...
参考文献标题:Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
文献作者:Rideout,J.L.; Pendergast,W.; Yerxa,B.R.; Siddiqi,S.M.(Inspire Pharmaceuticals,Inc.)
参考来源:JP 2001526635; US 6348589; WO 9834942

新产品编号:766197

Chemical Name: (+)-2-(2,4-Difluorophenyl)-1,1-difluoro-1-(2-thienyl)-3-(1H-1,2,4-triazol-1-yl)-2-propanol
CAS No. 294182-50-6, 294182-67-5 (non-specified. stereoch.)
项目整合开发状态: Biological Testing...
参考文献标题:New antifungal 1,2,4-triazoles with difluro(heteroaryl)methyl moiety
文献作者:Eto,H.; Kaneko,Y.; Sakamoto,T.
参考来源:Chem Pharm Bull 2000,48(7),982

新产品编号:125487

Chemical Name: 5-[4-(5-Methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]thiazolidine-2,4-dione hydrochloride
CAS No. 172647-71-1 (free base), 172647-73-3 (fumarate), 193544-60-4 (fumara...
参考文献标题:Heterocyclic cpds.having antidiabetic activity,their preparation and their use
文献作者:Fujita,T.; Fujimoto,K.; Yoshioka,T.; Yanagisawa,H.; Fujiwara,T.; Horikoshi,H.; Oguchi,M.; Wada,K.(Sankyo Co.,Ltd.)
参考来源:CA 2146701; EP 0676398; JP 1995330728; US 5624935; US 5834501; US 5962470; US 6117893

新产品编号:691843

Chemical Name: (Z)-3-[2-(5-Bromo-2-oxo-2,3-dihydro-1H-indol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]propionic acid
CAS No. 258830-93-2
项目整合开发状态: Biological Testing
项目研究机构: Sugen (Or...
参考文献标题:3-Methylidenyl-2-indolinone modulators of protein kinase
文献作者:Miller,T.A.; Tang,P.C.; Sun,L.; Tran,N.M.; Liang,C.; Nguyen,A.T.; Nematalla,A.(Sugen,Inc.)
参考来源:WO 0008202