项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

T-0902611, T-611, T-902611

Chemical Name: 4-[4-(1H-Imidazol-1-yl)-6-methyl-5-nitropyrimidin-2-yl]-3(S)-methylmorpholine benzenesulfonate
CAS No. 350595-61-8, 350595-60-7 (free base), 350607-79-3 (hydrobromide), 350607-80-6 (...
参考文献标题:Arylsulfonic acid salts of pyrimidine-based antiviral agents
文献作者:Powers,J.P.(Tularik Inc.)
参考来源:US 6410726; WO 0151485

Oxeglitazar, EMD-336340, LM-4156

Chemical Name: 5-(7-Methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl-2(E),4(E)-pentadienoic acid
CAS No. 280585-34-4
项目整合开发状态: Preclinical
项目研究机构: Merck KGaA (Originator)
合成路线:...
参考文献标题:Benzopyrans and benzoxepines,pharmaceutical compsns.comprising them and preparation process
文献作者:Guerrier,D.; Brunet,M.; Augert,G.; Zeiller,J.J.; Berthelon,J.J.; Contard,F.(Merck Patent GmbH)
参考来源:EP 1140893; FR 2787789; JP 2003517449; US 6596758; WO 0039113

IL-488

Chemical Name: 8-(2,4-Dimethoxy-6-methylphenyl)-2,7-dimethyl-N-[1(R)-methylpropyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
CAS No. 234774-18-6
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb ...
参考文献标题:Azolo triazines and pyrimidines
文献作者:He,L.; Arvanitis,A.G.; Chorvat,R.; Gilligan,P.(DuPont Pharmaceuticals Co.)
参考来源:EP 1049699; WO 9938868

SCH-205528

Chemical Name: N-[3(R)-(3,4-Dichlorophenyl)-5-[4-(2-oxopiperidin-1-yl)piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide
CAS No. 226915-45-3, 263892-22-4 ((R)-isomer), 226915...
参考文献标题:Substd.oximes as neurokinin antagonists
文献作者:Carruthers,N.I.; Alaimo,C.A.; Shih,N.-Y.; Lavey,B.J.; Ting,P.C.; Reichard,G.A.(Schering Corp.)
参考来源:EP 1032561; WO 9926924

A-293507

Chemical Name: 4-(4-Chlorophenoxy)-N'-hydroxythieno[2,3-c]pyridine-2-carboxamidine
CAS No. 251994-96-4
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator), Lilly (Originator)
合成路线:The formyl...
参考文献标题:Cell adhesion-inhibiting antiinflammatory cpds.
文献作者:Lartey,K.; Gunawardana,I.W.; Stout,D.M.; Bhatia,P.; Patel,M.V.; Staeger,M.A.; Boyd,S.A.; Mort,N.A.; Zhu,G.-D.; McCarty,C.M.; Stewart,A.O.; Arendsen,D.L.; Condroski,K.R.; Freeman,J.C.(Abbott Laboratories Inc.)
参考来源:WO 9962908

CT-747

Chemical Name: N-[5,5-Dimethyl-3-(4-methylphenylsulfonyl)thiazolidin-4(R)-ylcarbonyl]-4-O-[3-(dimethylamino)propyl]-L-tyrosine
CAS No. 220397-12-6
项目整合开发状态: Preclinical
项目研究机构: Elan (Originat...
参考文献标题:Substd.phenylalanine type cpds.which inhibit leukocyte adhesion mediated by VLA-4
文献作者:Ashwell,S.; Konradi,A.W.; Lombardo,L.J.; Dappen,M.S.; Baudy,R.B.; Kreft,A.; Grant,F.S.; Sarantakis,D.; Pleiss,M.A.; Semko,C.M.; Dressen,D.B.; Thorsett,E.D.(American Home Products Corp.; Athena Neurosciences,Inc.)
参考来源:WO 9906431

PNU-183792

Chemical Name: N-(4-Chlorobenzyl)-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
CAS No. 282536-25-8
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The 4...
参考文献标题:4-Oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
文献作者:Turner,S.R.; Strohbach,J.W.; Scott,A.; Schnute,M.E.; Vaillancourt,V.A.; Thaisrivongs,S.(Pharmacia Corp.)
参考来源:EP 1140851; WO 0040563

PD-0210293

Chemical Name: N1-[3-(1-Benzofuran-2-yl)-6,7-dichloroquinoxalin-2-yl]-N4,N4-diethylbutane-1,4-diamine
CAS No. 239095-01-3, 239095-83-1 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构: Pfi...
参考文献标题:Structure-activity relationship of 2-amino-3-heteroaryl-quinoxalines as potent,non-peptide interleukine-8-receptor antagonists
文献作者:Li,J.J.; Yue,W.-S.; Trivedi,B.K.; et al.
参考来源:220th ACS Natl Meet (Aug 20 2000,Washington DC) 2000,Abst MEDI 144

AP-22408

Chemical Name: 4-[2(S)-(Acetamido)-3-[3-(aminocarbonyl)-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-5(S)-ylamino]-3-oxopropyl]benzene-1,2-diphosphonic acid
CAS No. 268741-43-1 参考文献标题:Bicyclic signal transduction inhibitors,compsns.containing them & uses thereof
文献作者:Bohacek,R.; Sawyer,T.K.; Yang,M.G.; Eyermann,C.J.; Sundaramoorthi,R.; Shakespeare,W.C.(Ariad Pharmaceuticals Inc.)
参考来源:WO 0027802

L-015

Chemical Name: 6-[1-(3-Ethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-3-methyl-2(E),4(E)-hexadienoic acid
CAS No. 252556-01-7
项目整合开发状态: Biological Testing
项目研究机构: L...
参考文献标题:Retinoids,methods for their production and use
文献作者:Zhi,L.; Farmer,L.J.(Ligand Pharmaceuticals,Inc.)
参考来源:US 6005007