PD-0210293

Chemical Name: N1-[3-(1-Benzofuran-2-yl)-6,7-dichloroquinoxalin-2-yl]-N4,N4-diethylbutane-1,4-diamine
CAS No. 239095-01-3, 239095-83-1 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The condensation of 4,5-dichloro-1,2-phenylenediamine (I) with diethyl oxalate (II) produced quinoxalinedione (III),which was brominated with PBr5 at 155 C to afford the dibromo derivative (IV).Displacement of one bromine group of (IV) with 4-(diethylamino)butylamine (V) furnished (VI).The remaining bromine of (VI) was then displaced with 5-(tributylstannyl)-2,2'-bithienyl (VII) to produce the title compound,isolated as the corresponding hydrochloride salt.

合成路线:The condensation of 4,5-dichloro-1,2-phenylenediamine (I) with diethyl oxalate (II) produced quinoxalinedione (III),which was brominated with PBr5 at 155 C to afford the dibromo derivative (IV).Displacement of one bromine group of (IV) with 4-(diethylamino)butylamine (V) furnished (VI).The remaining bromine of (VI) was then displaced with 2-(tributylstannyl)benzofuran (VII) to produce the title compound.