新产品编号:766197

Chemical Name: (+)-2-(2,4-Difluorophenyl)-1,1-difluoro-1-(2-thienyl)-3-(1H-1,2,4-triazol-1-yl)-2-propanol
CAS No. 294182-50-6, 294182-67-5 (non-specified. stereoch.)
项目整合开发状态: Biological Testing
项目研究机构: SSP (Originator)
合成路线:The copper-promoted coupling between 2-iodothiophene (I) and ethyl bromodifluoroacetate (II) produced ethyl 2,2-difluoro-2-(2-thienyl)acetate (III).Addition of the organolithium reagent derived from 2,4-difluorobromobenzene (IV) to ester (III) yielded ketone (V).This was converted into the oxirane (VI) by reaction with dimethyloxosulfonium methylide in DMSO.Finally,oxirane ring opening with 1,2,4-triazole (VII) provided the title compound.