Denufosol tetrasodium, dCp4U, INS-37217

Chemical Name: P1-(2'-Deoxycytidin-5'-yl)-P4-(uridin-5'-yl)tetraphosphate tetrasodium salt; Uridine 5'-(pentahydrogen tetraphosphate) P'''--5'-ester with 2'-deoxycytidine tetrasodium salt
CAS No. 318250-11-2, 211448-85-0 (free acid)
项目整合开发状态: Phase III
项目研究机构: Inspire Pharmaceuticals (Orphan Drug), Inspire Pharmaceuticals (Originator)
合成路线:Uridine-5'-triphosphate (I) is converted to the tributylamine salt,which is then activated as the cyclic metaphosphate (II) employing DCC.Subsequent coupling of the cyclic phosphate (II) with 2'-deoxycytidine-5'-monophosphate (III) in the presence of Bu3N gives rise to the target tetraphosphate compound.