项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:655457

Chemical Name: 2(S)-[4'-(2-Benzyl-1-benzofuran-3-yl)biphenyl-4-yloxy]-3-phenylpropionic acid
CAS No. 250341-82-3, 250341-96-9 (enantiomer)
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals ...
参考文献标题:Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
文献作者:McDevitt,R.E.; Malamas,M.S.; Adebayo,F.O.(American Home Products Corp.)
参考来源:WO 9958518

新产品编号:318491

Chemical Name: N'-[1-[4(S)-(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyloxy)-2(S),5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-2-yl]-2-hydroxyethylidene]-2-[4-(2,5-dioxo-...
参考文献标题:Synthesis and stability of four maleimide derivatives of the anticancer drug doxorubicin for the preparation of cemoinmunoconjugates
文献作者:Kratz,F.; Schumacher,P.; Beyer,U.; Zahn,H.; Unger,C.; Kr黦er,M.
参考来源:Chem Pharm Bull 1997,45(2),399-401

新产品编号:725065

Chemical Name: 1-[6-(4-Chlorobenzylamino)-9-isopropyl-9H-purin-2-yl]-3-methyl-1-pentyn-3-ol
CAS No. 267885-31-4
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator)
合成路线:Condensation of ...
参考文献标题:Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2 - Inhibitor complex
文献作者:Legraverend,M.; Tunnah,P.; Noble,M.; Ducrot,P.; Ludwig,O.; Grierson,D.S.; Leost,M.; Meijer,L.; Endicott,J.
参考来源:J Med Chem 2000,43(7),1282

新产品编号:788345

Chemical Name: cis-3-[4-[6-Methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl]cyclohexyl]-1H-indole-5-carbonitrile
CAS No. 302916-76-3, 302916-77-4 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Wyeth...
参考文献标题:Tetrahydroisoquinolinyl-indole derivs.for the treatment of depression
文献作者:Meagher,K.L.; Mewshaw,R.E.(American Home Products Corp.)
参考来源:WO 0064886

QW-1624F2-2

Chemical Name: (+)-(1alpha,3beta)-24,24-Difluoro-25-hydroxy-1-(hydroxymethyl)-26,27-dimethyl-16,17-didehydrovitamin D3
CAS No. 212124-60-2
项目整合开发状态: Preclinical
项目研究机构: Johns Hopkins Universi...
参考文献标题:Non-calcemic,antiproliferative,transcriptionally active 24-fluorinated hybrid analogs of 1alpha,25-dihydroxyvitamin D3
文献作者:Wang,Q.; Lee,J.K.; Posner,G.H.(Johns Hopkins University)
参考来源:US 6043386

新产品编号:226735

Chemical Name: (1R,2S,3S)-3-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)cyclopentanamine
CAS No. 190271-62-6
项目整合开发状态: Preclinical 参考文献标题:Cyclopentyl tachykinin receptor antagonists
文献作者:Finke,P.E.; Maccoss,M.; Meurer,L.C.; Mills,S.G.; Caldwell,C.G.; Chen,P.; Durette,P.L.; Hale,J.; Holson,E.; Kopka,I.; Robichaud,A.(Merck & Co.,Inc.)
参考来源:EP 0858444; WO 9714671

新产品编号:511495

Chemical Name: N-Ethyl-N-[1-[4-hydroxy-3-[N-methyl-N-(phenylsulfonyl)aminomethyl]-3-phenylbutyl]piperidin-4-yl]carbamic acid benzyl ester enantiomer A
CAS No. 220394-36-5 ((R)-isomer), 220394-35-4 ...
参考文献标题:Discovery of potent human CCR5 antagonists for the treatment of HIV-1 infection-IV
文献作者:Cladwell,C.G.; Chen,P.; Donnelly,K.F.; et al.
参考来源:219th ACS Natl Meet (March 26 2000,San Francisco) 2000,Abst MEDI 120

Ro-64-6198

Chemical Name: 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS No. 228246-60-4 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: CeNeS (Orig...
参考文献标题:8-Substd.-1,3,8-triazaspiro[4.5]decan-4-on derivs.
文献作者:Adam,G.; Monsma,F.; Wichmann,J.; Jenck,F.; Galley,G.; Cesura,A.; R鰒er,S.(F.Hoffmann-La Roche AG)
参考来源:EP 0856514; US 6071925

GFB-111

Chemical Name: 1,1',1'',1'''-[[25,26,27,28-Tetrabutoxypentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19,(26),21,23-dodecaene-5,11,17,23-tetrayl]tetrakis[carbonyli...
参考文献标题:Protein surface recognition by synthetic receptors: A route to novel submicromolar inhibitors for alpha-chymotrypsin
文献作者:Park,H.S.; et al.
参考来源:J Am Chem Soc 1999,121(1),8

新产品编号:494093

Chemical Name: 4-Amino-N-[1-[1-(4-aminobutyl)piperidin-4-ylmethyl]piperidin-4-yl]-5-chloro-2-methoxybenzamide
CAS No. 220027-02-1
项目整合开发状态: Preclinical
项目研究机构: Dainippon Pharmaceutical (Origi...
参考文献标题:Benzamido derivs.and medicinal compsns.containing the same
文献作者:Kato,S.; Yoshida,N.; Harada,H.; Toyotomi,Y.; Morikage,S.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:JP 1999001472