项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:10001

Chemical Name: 2-Undecenal semicarbazone
CAS No. 100248-25-7
项目整合开发状态: Preclinical
项目研究机构: National Institutes of Health (Originator), University of Saskatchewan (Originator)
合成路线:The titl...
参考文献标题:Anticonvulsant properties of various acetylhydrazones,oxamoylhydrazones and semicarbazones derived from aromatic an unsaturated carbonyl compounds
文献作者:Dimmock,J.R.; Vashishtha,S.C.; Stables,J.P.
参考来源:Eur J Med Chem 2000,35(2),241

PNU-145185

Chemical Name: N-(4-Chlorobenzyl)-8-fluoro-4-hydroxyquinoline-3-carboxamide
CAS No. 228725-44-8
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The condensation of 2-fluoroan...
参考文献标题:4-Hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
文献作者:Schnute,M.E.; Turner,S.R.; Cudahy,M.M.; Vaillancourt,V.A.; Thaisrivongs,S.; Strohbach,J.W.; Romines,K.R.; Tucker,J.A.(Pharmacia Corp.)
参考来源:EP 1042295; US 6093732; WO 9932450

WAY-141608

Chemical Name: 1-[6,11-Dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl]-1-[4-(3-methyl-1H-pyrazol-1-yl)-2-(trifluoromethyl)phenyl]methanone
CAS No. 220602-65-3
项目整合开发状态: Preclinical
项目研究机构: W...
参考文献标题:Tricyclic vasopressin agonists
文献作者:Failli,A.A.; Shumsky,J.S.; Steffan,R.J.(American Home Products Corp.)
参考来源:EP 1000059; WO 9906403

NMI-678-11

Chemical Name: 2-[2-[2-Methyl-2-(nitrososulfanyl)propylamino]-2-oxoethoxy]acetic acid 4-[2-(dimethylamino)ethoxy]-5-isopropyl-2-methylphenyl ester succinate
CAS No. 260267-68-3
项目整合开发状态: Preclin...
参考文献标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonists,compsns.and methods of use
文献作者:Gaston,R.D.; Saenz de Tejada,I.; Schroeder,J.D.; Shelekhin,T.E.; Garvey,D.S.; Wang,T.(NitroMed Inc.)
参考来源:WO 0012075

NMI-937-11

Chemical Name: 1-[3-Methyl-3-(nitrososulfanyl)butyryl]piperidine-4-carboxylic acid 4-[2-(dimethylamino)ethoxy]-5-isopropyl-2-methylphenyl ester succinate
CAS No. 260267-87-6 (free base)
项目整合开发状态...
参考文献标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonists,compsns.and methods of use
文献作者:Gaston,R.D.; Saenz de Tejada,I.; Schroeder,J.D.; Shelekhin,T.E.; Garvey,D.S.; Wang,T.(NitroMed Inc.)
参考来源:WO 0012075

Rec-2615, Rec-15/2615

Chemical Name: 1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-[2-(isopropyl)-6-methoxyphenoxy]ethan-1-one hydrochloride
CAS No. 173059-17-1, 173059-47-7 (free base)
项目整合开发状态: Precl...
参考文献标题:Quinazolinyl-amino derivs.having alpha-antagonist activity
文献作者:Leonardi,A.; Motta,G.; Boi,C.; Testa,R.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:EP 0750614; JP 1997511238; US 5798362; WO 9525726

TBC-3342

Chemical Name: 3(S)-(1,3-Benzodioxol-5-yl)-3-[3-[2-(benzylsulfanyl)-1(S)-(phenylsulfanylmethyl)ethyl]ureido]propionic acid
CAS No. 247094-08-2
项目整合开发状态: Biological Testing
项目研究机构: Encysive Ph...
参考文献标题:N,N-Disubstd.amides that inhibit the binding of integrins to their receptors
文献作者:Raju,B.G.; Scott,I.L.; Biediger,R.J.; Market,R.V.; Grabbe,V.O.; Kassir,J.M.; Kogan,T.P.; Lin,S.(Texas Biotechnology Corp.)
参考来源:US 6096773; WO 9952493; WO 9952898

新产品编号:658621

Chemical Name: [3,3''-Dichloro-5'-(dodecylcarbamoyl)[1,1':3',1''-terphenyl]-2'-yloxy]acetic acid
CAS No. 251475-05-5
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:B...
参考文献标题:2,3,5-Substd.biphenyls useful in the treatment of insulin resistance and hyperglycemia
文献作者:Butera,J.A.; Caufield,C.E.; Greenfield,A.; Gundersen,E.G.; Lennox,J.R.; Graceffa,R.F.; Mayer,S.C.; Katz,A.H.; McDevitt,R.E.; Havran,L.M.(American Home Products Corp.)
参考来源:WO 9961410

NSC-708199

Chemical Name: (+)-2-Methyl-3(S)-(3-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
CAS No. 256221-01-9, 256221-00-8 (racemate)
项目整合开发状态: Biological Testing
项目研究机构: University of Te...
参考文献标题:Methods of synthesizing sultams and anti-viral compsns.
文献作者:Johnson,S.C.; Yan,S.; Mayasundari,A.; Mao,J.; Baker,D.C.(University of Tennessee,Knoxville)
参考来源:WO 0004004

新产品编号:660203

Chemical Name: 3-[1-(4-Fluorobenzyl)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl]-4-propoxybenzamide
CAS No. 252232-48-7
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Orig...
参考文献标题:Quinazolinone inhibitors of cGMP phosphodiesterase
文献作者:Weller,H.N.III; Rotella,D.P.; Yevich,J.P.; Cushman,D.W.; Macor,J.E.(Bristol-Myers Squibb Co.)
参考来源:US 6087368; WO 9964004