Rec-2615, Rec-15/2615
Chemical Name: 1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-[2-(isopropyl)-6-methoxyphenoxy]ethan-1-one hydrochloride
CAS No. 173059-17-1, 173059-47-7 (free base)
项目整合开发状态: Preclinical
项目研究机构: Recordati (Originator)
合成路线:The alkylation of 2-isopropyl-6-methoxyphenol (I) with ethyl bromoacetate (II) under phase-transfer conditions in the presence of NaOH provided (aryloxy)acetic acid (III) which,upon treatment with SOCl2,was converted into acid chloride (IV).Coupling of (IV) with 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (V) then furnished the target amide.The title compound was finally isolated as the hydrochloride salt.
📌 参考资料/链接：
参考文献标题:Quinazolinyl-amino derivs.having alpha-antagonist activity
文献作者:Leonardi,A.; Motta,G.; Boi,C.; Testa,R.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:EP 0750614; JP 1997511238; US 5798362; WO 9525726
📄 详细内容
合成路线:The alkylation of 2-isopropyl-6-methoxyphenol (I) with ethyl bromoacetate (II) under phase-transfer conditions in the presence of NaOH provided (aryloxy)acetic acid (III) which,upon treatment with SOCl2,was converted into acid chloride (IV).Coupling of (IV) with 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (V) then furnished the target amide.The title compound was finally isolated as the hydrochloride salt.
参考文献标题:Synthesis,pharmacological evaluation,and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists
文献作者:Leonardi,A.; Motta,G.; Boi,C.; Testa,R.; Poggesi,E.; De Benedetti,P.G.; Menziani,M.C.
参考来源:J Med Chem 2000,42(3),427
产品链接: CAS No. 173059-17-1›› 产品链接: CAS No.173059-47-7››