新产品编号:725065
Chemical Name: 1-[6-(4-Chlorobenzylamino)-9-isopropyl-9H-purin-2-yl]-3-methyl-1-pentyn-3-ol
CAS No. 267885-31-4
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator)
合成路线:Condensation of 6-chloro-2-iodo-9-isopropylpurine (I) with 4-chlorobenzylamine (II) in hot EtOH afforded the 6-(benzylamino)purine (III).Subsequent Suzuki coupling of (III) with 3-methylpent-1-yn-3-ol (IV) in the presence of Pd(0) and CuI produced the target 2-ethynylpurine derivative.
📌 参考资料/链接：
参考文献标题:Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2 - Inhibitor complex
文献作者:Legraverend,M.; Tunnah,P.; Noble,M.; Ducrot,P.; Ludwig,O.; Grierson,D.S.; Leost,M.; Meijer,L.; Endicott,J.
参考来源:J Med Chem 2000,43(7),1282