项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

S-1401

Chemical Name: 5'-O-[3,4-Bis(benzyloxy)benzyl]thymidylyl-(3'-5')-2'-deoxyguanylyl-(3'-5')-2'-deoxyguanylyl-(3'-5')-2'-deoxyguanylyl-(3'-5')-2'-deoxyadenylyl-(3'-5')-2'-deoxyguanosine penta(N,N-diethyl...
参考文献标题:Modified oligodeoxyribonucleotides,their preparat
文献作者:Furukawa,H.; Momota,K.; Hotoda,H.; Koizumi,M.; Kaneko,M.(Sankyo Co.,Ltd.)
参考来源:EP 0611075; JP 1995053587; JP 1995087982; US 5674856; US 5807837

新产品编号:247301

Chemical Name: N-[5-Amino-5-methyl-2(E)-hexenoyl]-N-methyl-3-(2-naphthyl)-D-alanyl-N-methyl-D-phenylalanine N-[2(S)-hydroxypropyl]amide
CAS No. 193079-05-9
项目整合开发状态: Preclinical
项目研究机构: Novo ...
参考文献标题:Cpds.with growth hormone releasing properties
文献作者:Hansen,T.K.; Peschke,B.; Lau,J.; Lundt,B.F.; Ankersen,M.; Watson,B.; Madsen,K.(Novo Nordisk A/S)
参考来源:JP 1999209336; JP 1999501054; JP 2000143613; US 6127391; WO 9723508

S-30972-1

Chemical Name: 9-(4-Carboxybutyryloxy)-N-[2-(dimethylamino)ethyl]-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide dihydrochloride; Pentanedioic acid [1-[N-[2-(dimethylamino)ethyl]carbamoyl]-5,6-d...
参考文献标题:Ellipticine derivs.,their preparation and pharmaceutical compsns.containing them
文献作者:Guilbaud,N.; Bisagni,E.; Guillonneau,C.; Charton,Y.; Atassi,G.; Pierre,A.(ADIR et Cie.)
参考来源:EP 0850940; US 6162811

PH-98

Chemical Name: 3-(2-Nitrophenyl)-1-(2,3,4-trimethoxyphenyl)-2(E)-propen-1-one
CAS No. 158117-42-1
项目整合开发状态: Preclinical
项目研究机构: Danish University of Pharmaceutical Sci. (Originator), Statens ...
参考文献标题:Antileishmanial chalcones: Statistical design,synthesis,and three-dimensional quantitative structure-activity relationship analysis
文献作者:Nielsen,S.F.; Christensen,S.B.; Gruciani,G.; Kharazmi,A.; Liljefors,T.
参考来源:J Med Chem 1998,41(24),4819

新产品编号:587431

Chemical Name: 4-(5-Fluoro-1H-indol-3-yl)-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]piperidine-1-carboxamide hydrochloride hydrate
CAS No. 228088-96-8 (anhydrous)
项目整合开发状态: Biological Testin...
参考文献标题:Amide and urea derivs.
文献作者:B鰐tcher,H.; Harting,J.; van Amsterdam,C.; Bartoszyk,G.; Greiner,H.; Rautenberg,W.; Matzen,L.(Merck Patent GmbH)
参考来源:DE 19756036

S-31354

Chemical Name: 3-[6-(4-Chlorophenylsulfonamido)-2-(2-nitrooxyethyl)-5,6,7,8-tetrahydro-1-naphthyl]propionic acid
CAS No. 213313-90-7
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
合成路线...
参考文献标题:Nouveaux d閞iv閟 de benz鑞sessulfonylamine,leur proc閐?depr閜aration et les compositions pharmaceutiques qui les contiennent
文献作者:Lavielle,G.; Cimetiere,B.; Verbeuren,T.; Simonet,S.; Descombes,J.-J.(ADIR et Cie.)
参考来源:EP 0864561

新产品编号:41641

Chemical Name: (1R,5S,6S)-2-[2(S)-[4-(Carbamoylmethyl)-4-methylhexahydro-1,4-diazepinium-1-ylcarbonyl]pyrrolidin-4(S)-ylsulfanyl]-6-[1(R)-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate hydrochlo...
参考文献标题:Carbapenem derivs.having antibiotic activity,their preparation and their use
文献作者:Kawamoto,I.; Miyauchi,M.; Nakayama,E.; Endo,R.; Ohya,S.; Utsui,Y.(Sankyo Co.,Ltd.)
参考来源:EP 0443883; JP 1992211083; US 5310735

RPR-130401

Chemical Name: (3aRS,4SR,9SR,9aRS)-2-[2-(2-Methoxyphenyl)-2-propenoyl]-9-(4-methylphenyl)-2,3,3a,4,9,9a-hexahydro-1H-4,9-ethanobenzo[f]isoindole-3a-carboxylic acid
CAS No. 210282-69-2
项目整合开发状态: ...
参考文献标题:Farnesyl transferase inhibitors
文献作者:Dereu,N.; Sounigo-Thompson,F.; Commer鏾n,A.; Martin,J.-P.; Bourzat,J.-D.; Capet,M.; Cheve,M.; Mailliet,P.(Aventis Pharma SA)
参考来源:EP 0948483; WO 9829390

SB-25314, SR-74829i

Chemical Name: 1-(2,6-Dimethylpyridin-3-ylamino)-1-(4-hydroxy-3-methoxy-5-methylphenyl)methylphosphonic acid diisopropyl ester
CAS No. 209624-38-4, 209624-57-7 ((R)-isomer), 209624-56-6 ((S)-isomer...
参考文献标题:Pharmaceutical aminophosphonic acid derivs.
文献作者:Nguyen,L.M.; Van Diep,V.; Phan,H.T.; Ife,R.J.; Bentzen,C.L.; Niesor,E.; Floret,S.; Azoulay,R.(SmithKline Beecham plc; Symphar SA)
参考来源:EP 0946572; WO 9828310

SR-103912

Chemical Name: 1-(2,6-Dimethylpyridin-3-ylamino)-1-(4-hydroxy-3-methoxy-5-methylphenyl)methylphosphonic acid diethyl ester
CAS No. 209624-59-9 ((R)-isomer), 209624-58-8 ((S)-isomer), 209624-37-3 (a...
参考文献标题:Pharmaceutical aminophosphonic acid derivs.
文献作者:Nguyen,L.M.; Van Diep,V.; Phan,H.T.; Ife,R.J.; Bentzen,C.L.; Niesor,E.; Floret,S.; Azoulay,R.(SmithKline Beecham plc; Symphar SA)
参考来源:EP 0946572; WO 9828310