PH-98
Chemical Name: 3-(2-Nitrophenyl)-1-(2,3,4-trimethoxyphenyl)-2(E)-propen-1-one
CAS No. 158117-42-1
项目整合开发状态: Preclinical
项目研究机构: Danish University of Pharmaceutical Sci. (Originator), Statens Serum Institute (Originator)
合成路线:Title compound was prepared by Claisen Schmidt condensation of 4'-cyclohexylacetophenone (I) with 3,5-dimethoxybenzaldehyde (II) in EtOH using NaOH as the catalyst.
合成路线:Title compound was prepared by Claisen Schmidt condensation of 2'-nitroacetophenone (I) with 2,3,4-trimethoxybenzaldehyde (II) in EtOH using HCl as the catalyst.
📌 参考资料/链接：
参考文献标题:Antileishmanial chalcones: Statistical design,synthesis,and three-dimensional quantitative structure-activity relationship analysis
文献作者:Nielsen,S.F.; Christensen,S.B.; Gruciani,G.; Kharazmi,A.; Liljefors,T.
参考来源:J Med Chem 1998,41(24),4819