新产品编号:587431
Chemical Name: 4-(5-Fluoro-1H-indol-3-yl)-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]piperidine-1-carboxamide hydrochloride hydrate
CAS No. 228088-96-8 (anhydrous)
项目整合开发状态: Biological Testing
项目研究机构: Merck KGaA (Originator)
合成路线:Treatment of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline dihydrochloride (I) with 1,1'-carbonyldiimidazole (II) gave the intermediate imidazolide (III) which,upon treatment with 4-(5-fluoro-1H-indol-3-yl)piperidine (IV) afforded the unsymmetrical urea.Finally,treatment with HCl in acetone yielded the title hydrochloride salt.
📌 参考资料/链接：
参考文献标题:Amide and urea derivs.
文献作者:B鰐tcher,H.; Harting,J.; van Amsterdam,C.; Bartoszyk,G.; Greiner,H.; Rautenberg,W.; Matzen,L.(Merck Patent GmbH)
参考来源:DE 19756036
📄 详细内容
合成路线:Treatment of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline dihydrochloride (I) with 1,1'-carbonyldiimidazole (II) gave the intermediate imidazolide (III) which,upon treatment with 4-(5-fluoro-1H-indol-3-yl)piperidine (IV) afforded the unsymmetrical urea.Finally,treatment with HCl in acetone yielded the title hydrochloride salt.
参考文献标题:5-HT reuptake inhibitors with 5-HT1B/1D antagonistic activity: A new approach toward efficient antidepressants
文献作者:Matzen,L.; van Amsterdam,C.; Rautenberg,W.; Greiner,H.E.; Harting,J.; Seyfried,C.AS.; B鰐tcher,H.
参考来源:J Med Chem 2000,43(6),1149