项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

ADN-311

Chemical Name: 2-[1-(3,4-Dichlorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl]acetic acid
CAS No. 136148-02-2
项目整合开发状态: Preclinical
项目研究机构: Kyorin (Originator)
合成路线:The reaction of ...
参考文献标题:Novel aldose reductase inhibitors: Synthesis and structure-activity studies of (3-benzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)acetic acids
文献作者:Itoh,Y.; Hashimoto,M.; Ao,S.; Notsu,Y.
参考来源:Drugs Fut 1992,17(1),31

NIP-520

Chemical Name: 5-[3-[2-(4-Benzylpiperazin-1-yl)-2-oxoethoxy]-4-methoxybenzylamino]-4-chloropyridazin-3(2H)-one hydrochloride
CAS No. 161831-35-2
项目整合开发状态: Phase I
项目研究机构: Nissan Chemical (Ori...
参考文献标题:Pyridazinone derivs.with pharmaceutical activity
文献作者:Tanikawa,K.; Saito,A.; Hirotsuka,M.; Shikada,K.(Nissan Chemical Industry,Ltd.)
参考来源:EP 0706517; JP 1996041033; US 5728702; US 5929074; WO 9501343

TK-2339, NSC-686288

Chemical Name: 5-Amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
CAS No. 165179-35-1
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator), National Cancer Insti...
参考文献标题:5-Aminoflavone derivs.,their preparation and their use as antibacterial,anti-estrogenic and/or antitumor agent
文献作者:Akama,T.; Ikeda,S.; Ishida,H.; Kimura,U.; Gomi,K.; Saito,H.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0638566; JP 1995109268

L-372662

Chemical Name: 1-[1-[2-Methoxy-4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]benzoyl]piperidin-4-yl]-2,4-dihydro-1H-3,1-benzoxazin-2-one
CAS No. 162045-26-3
项目整合开发状态: Preclinical 参考文献标题:Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
文献作者:Bock,M.G.; Evans,B.E.; Hobbs,D.W.; Williams,P.D.; Anderson,P.S.; Freidinger,R.M.; Pettibone,D.J.(Merck & Co.,Inc.)
参考来源:EP 0714299; JP 1997500134; US 5665719; WO 9502405

SY-726, SSY-726

Chemical Name: (-)-(R)-3-Methyl-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-[4-(trifluoromethyl)phenyl]-2-butanol
CAS No. 136067-88-4
项目整合开发状态: Discontinued
项目研究机构: Mitsubishi Pharma (Origina...
参考文献标题:Triazole derivs.
文献作者:Tokizawa,M.; Kanamaru,Y.; Matsumoto,M.; Asaoka,T.; Matsuda,H.; Kuraishi,T.; Maebashi,K.; Taido,N.; Kawahara,R.(SSP Co.,Ltd.)
参考来源:EP 0435081; JP 1991223266; US 5147886

JWS-USC-75IX

Chemical Name: N-[2-[5-(Dimethylaminomethyl)-2-furylmethylsulfanyl]ethyl]-4-nitropyridazin-3-amine
CAS No. 142744-34-1
项目整合开发状态: Preclinical
项目研究机构: University of Georgia (Originator), Univer...
参考文献标题:Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine
文献作者:Valli,M.J.; Tang,Y.; Kosh,J.W.; Chapman,J.M.Jr.; Sowell,W.
参考来源:J Med Chem 1992,35(17),3141

Roxatidine bismuth citrate, MX1

Chemical Name: 2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide 2-hydroxypropane-1,2,3-tricarboxylic acid bismuth (3+) complex (1:1:1)
CAS No. 178487-37-1, 164066-67-5 (error)
项目整...
参考文献标题: N-(3-(3-(1-Piperidinylmethyl)phenoxy)propyl)propenetricarboxylate bismuth (3+) complex and the method for preparation
文献作者:Ivanov,C.B.; Lutakov,G.I.; Nikolov,G.N.; Atanassova,R.B.; Petkov,O.V.; Taskov,M.V.; Ninova,E.A.; Tomova,V.V.; Aneva,V.T.; Mondeschka,D.M.; Schopova,S.I.; Bachvarova,A.S.; Galabova,A.A.; et al.(Chemical Pharmaceutical Research Institute)
参考来源:WO 9509162

新产品编号:81191

Chemical Name: N-[4-[5-(3-Pyridylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-5-ylcarbonyl]phenyl]biphenyl-2-carboxamide
CAS No. 159589-32-9
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Origi...
参考文献标题:Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: Synthesis and pharmacological properties of 2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide derivatives
文献作者:Matsuhisa,A.; Koshio,H.; Sakamoto,K.; Taniguchi,N.; Yatsu,T.; Tanaka,A.
参考来源:Chem Pharm Bull 1998,46(10),1566

TER-930180

Chemical Name: 3-[4-[1-(4-Chlorophenylsulfonamidomethyl)-4-(3-pyridyl)butyl]phenyl]propionic acid
CAS No. 172283-12-4
项目整合开发状态: Preclinical
项目研究机构: Terumo (Originator)
合成路线:As shown in Sch...
参考文献标题:N-(3-Pyridylalkyl)sulfonamide deriv.and pharmaceutical preparation containing thereof
文献作者:Ohnishi,H.; Miyakoshi,M.; Isozaki,M.; Fujitake,M.; Mikami,N.; Yanoshita,R.; Akasofu,H.; Sugizaki,K.; Nakata,N.(Terumo Corp.)
参考来源:EP 0501876; JP 1992270265; JP 1993043546; JP 1993043547; US 5374641

YM-31758

Chemical Name: 4-(Biphenyl-4-yloxy)-3-chlorobenzoic acid
CAS No. 158770-59-3
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:The arylation of 4-phenylphenol (I) with 3,4-dichlor...
参考文献标题:A novel class of inhibitors for human steroid 5alpha-reductase: Phenoxybenzoic acid derivatives.I
文献作者:Igarashi,S.; Kimura,T.; Naito,R.; Hara,H.; Fujii,M.; Koutoku,H.; Oritani,H.; Mase,T.
参考来源:Chem Pharm Bull 1999,47(8),1073