项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

OSA-8302

Chemical Name: 13,14-Dihydroprostaglandin F2beta isopropyl ester; (5Z,9beta,11alpha,15S)-9,11,15-Trihydroxyprost-5-en-1-oic acid isopropyl ester
CAS No. 162478-72-0
项目整合开发状态: Preclinical
项目研究...
参考文献标题:13,14-Dihydro-PGF2BETA and its isopropyl ester
文献作者:Miyazaki,T.; Kawakura,M.; Shirasawa,E.(Ono Pharmaceutical Co.,Ltd.)
参考来源:CA 2125804; EP 0628545; JP 1995061965

V-11294A

Chemical Name: 3-[3-(Cyclopentyloxy)-4-methoxybenzyl]-6-(ethylamino)-8-isopropyl-3H-purine hydrochloride
CAS No. 162278-09-3
项目整合开发状态: Phase I
项目研究机构: Euroceltique (Originator), Napp (Codevel...
参考文献标题:Novel chemical cpds.having PDE-IV inhibition activity
文献作者:Cavalla,D.; Hoefer,P.; Gehrig,A.; Wintergest,P.(Euroceltique SA)
参考来源:EP 0705265; JP 1997500376; US 5939422; WO 9500516

MDL-75204DA ((-)-enantiomer), MDL-74722DA ((+)-enantiomer), MDL-74180DA

Chemical Name: (?-3-(4-Methyl-1-piperazinylmethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-ol dihydrochloride monohydrate
CAS No. 153490-72-3 (anhydrous), 153490-90-5 (anhydrous, (R)-isome...
参考文献标题:Novel process for preparing derivatives of 2,2,4,6,7-pentaalkyl-2,2-dihydrobenzofuranols
文献作者:Ayers,T.A.; Schnettler,R.A.; Marciniak,G.; Krysan,D.J.(Hoechst Marion Roussel Inc.)
参考来源:EP 0813530

Mozenavir mesilate, DMP-450, XM-412(free base)

Chemical Name: (4R,5S,6S,7R)-1,3-Bis(3-aminobenzyl)-4,7-dibenzyl-5,6-dihydroxyhexahydro-1,3-diazepin-2-one dimethanesulfonate
CAS No. 153182-59-3 (diHCl), 174391-92-5 (free base)
项目整合开发状态: Phase...
参考文献标题:Cyclic ureas and analogues useful as retroviral protease inhibitors
文献作者:Lam,P.Y.; Eyermann,C.J.; Hodge,C.N.; Jadhav,P.K.; DeLucca,G.V.(DuPont Pharmaceuticals Co.)
参考来源:EP 0607334; EP 0686151; EP 0765873; JP 1995500324; JP 1996509700; US 5610294; WO 9307128; WO 9419329

KT-6352

Chemical Name: 9,13-Epoxy-10-methoxy-2,9-dimethyl-11-(methylamino)-2,3,10,11,12,13-hexahydro-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
CAS No. 161510-80-1
项目整合开发...
参考文献标题:Staurosporin derivatives
文献作者:Murakata,C.; Sato,A.; Kasai,M.; Morimoto,M.; Akinaga,S.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0383919; JP 2766360B2; WO 8907105

Pumosetrag hydrochloride, MKC-733

Chemical Name: 7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride
CAS No. 194093-42-0, 153062-94-3 (free base), 153062-96-5 (free base, (S)-isomer), 152995-74...
参考文献标题:Thieno[3,2-b]pyridine derivs.for the treatment of gastrointestinal disorders
文献作者:Maruyama,A.; Ogawa,S.; Yamazaki,S.; Tobe,A.(Mitsubishi Chemical Corp.)
参考来源:EP 0560348; JP 1993310747; US 5352685

MR-18445

Chemical Name: 4-[4-(4-Fluorobenzyl)piperazin-1-yl]-7-methoxypyrrolo[1,2-a]quinoxaline
CAS No. 160656-76-8, 190135-40-1 (as dihydrochloride), 212620-15-0 (labeled)
项目整合开发状态: Preclinical
项目研究机...
参考文献标题:Pyrrolopyrazine derivs.with 5-HT3 activity
文献作者:Rault,S.; Lancelot,J.-C.; Prunier,H.; Robba,M.; Delagrange,P.; Renard,P.; Adam,G.(ADIR et Cie.)
参考来源:CA 2122890; EP 0623620; FR 2704547; JP 1994340666; US 5599812

KF-20444

Chemical Name: 10-Fluoro-3-(2-fluorophenyl)-6,7-dihydro-5H-benz[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid
CAS No. 154015-73-3
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator)
...
参考文献标题:Tetracyclic cpds.
文献作者:Suzuki,F.; Nakasato,Y.; Tsumuki,H.; Ohmori,K.; Nakajima,H.; Tamura,T.; Sato,S.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:US 5371225; WO 9322286

YM-32906

Chemical Name: 4-(1-Benzylindol-5-yloxy)-3-chlorobenzoic acid
CAS No. 161459-96-7
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:The N-benzyl indole derivative (III) was prepar...
参考文献标题:A novel class of inhibitors for human steroid 5alpha-reductase: Synthesis and biological evaluation of indole derivatives.II
文献作者:Igarashi,S.; Inami,H.; Hara,H.; Fujii,M.; Koutoku,H.; Oritani,H.; Mase,T.
参考来源:Chem Pharm Bull 2000,48(3),382

G-7453

Chemical Name: 3-[8-(4-Amidinobenzamido)-6-oxo-5,6-dihydro-4H-tetrazolo[1,5-a][1,4]benzodiazepin-5-yl]propionic acid
CAS No. 167854-60-6
项目整合开发状态: Preclinical
项目研究机构: Genentech (Originator) 参考文献标题:Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
文献作者:Robarge,K.D.; Dina,M.S.; Somers,T.C.; Lee,A.; Rawson,T.E.; Olivero,A.G.; Tischler,M.H.; Webb,R.R.II; Weese,K.J.; Aliagas,I.; Blackburn,B.K.
参考来源:Bioorg Med Chem 1998,6(12),2345