Pumosetrag hydrochloride, MKC-733
Chemical Name: 7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride
CAS No. 194093-42-0, 153062-94-3 (free base), 153062-96-5 (free base, (S)-isomer), 152995-74-9 (free base, racemic)
项目整合开发状态: Phase II
项目研究机构: Mitsubishi Pharma (Originator), Janssen (Licensee)
合成路线:MKC-733 is synthesized by condensation of 7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylic acid (I) with quinuclidin-3(R)-amine (II) by means of carbonyldimidazole in DMF.
📌 参考资料/链接：
参考文献标题:Thieno[3,2-b]pyridine derivs.for the treatment of gastrointestinal disorders
文献作者:Maruyama,A.; Ogawa,S.; Yamazaki,S.; Tobe,A.(Mitsubishi Chemical Corp.)
参考来源:EP 0560348; JP 1993310747; US 5352685
📄 详细内容
合成路线:MKC-733 is synthesized by condensation of 7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylic acid (I) with quinuclidin-3(R)-amine (II) by means of carbonyldimidazole in DMF.
参考文献标题:MKC-733
文献作者:Rabasseda,X.; Castar,J.; Revel,L.
参考来源:Drugs Fut 1999,24(9),966