新产品编号:81191

Chemical Name: N-[4-[5-(3-Pyridylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-5-ylcarbonyl]phenyl]biphenyl-2-carboxamide
CAS No. 159589-32-9
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:Alkylation of benzodiazepinone (I) with 3-(chloromethyl)- pyridine (II) in the presence of NaH gave the 1-substituted benzodiazepinone (III).Reduction of the amide group of (III) with borane in THF afforded benzodiazepine (IV).Subsequent condensation with 4-nitrobenzoyl chloride (V) gave nitrobenzamide (VI),which was reduced to amine (VII) by hydrogenation in the presence of Pd/C.This compound was coupled with acid chloride (IX) (prepared by treatment of 2-phenylbenzoic acid (VIII) with oxalyl chloride) to yield the title compound.