项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Lamifiban, Ro-44-9883/023(mono HCl salt), Ro-44-9883/000, Ro-44-9883, Lamstat

醋酸,2-[[1-[(2S)-2-[[4-(氨基亚胺甲基)苯甲酰]氨基]-3-(4-羟基苯基)-1-氧丙基]-4-哌啶基]- 醋酸,2-[[1-[(2S)-2-[[4-(氨基亚胺甲基)苯甲酰]氨基]-3-(4-羟基苯基)-1-氧丙基]-4-哌啶基]氧]-盐酸盐(1:1) Chemical Name: 2-[1-[N-(4-Amidinobenzoyl)-L-tyrosyl]piperidin-4-...
参考文献标题:N-acyl-alpha-aminoacids derivs.
文献作者:Alig,L.; Hadvary,P.; H鼁eler,M.; M黮ler,M.; Steiner,B.; Weller,T.(F.Hoffmann-La Roche AG)
参考来源:EP 0505868; JP 1993148204; US 5378712; US 5545658; US 5658928; US 5670515; US 5747522

Pimilprost, SM-10902, Skipron

醋酸,2-[2-[(2R,3aS,4R,5R,6aS)-辛氢-5-羟基-4-[(1E,3S,5S)-3-羟基-5-甲基-1-徨-1-1-基]-2-戊二烯基]乙氧基]-,甲基酯Chemical Name: 17(S),20-Dimethyl-6a-carba-3-oxaprostaglandin I1 methyl ester; 2-[2-[(3aS,6aS)-5(R)-Hydroxy-6(R)-[...
参考文献标题:Bicyclooctane derivs.and their production and use
文献作者:Muraoka,M.; Nakamura,T.; Sugie,A.; Ono,K.; Yamamoto,M.(Sumitomo Pharmaceuticals Co.,Ltd.)
参考来源:EP 0115954

Uliprisnil acetate, RTI-3021-012, CDB-2914

醋酸乌利司他Chemical Name: 17alpha-Acetoxy-11beta-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione
CAS No. 126784-99-4
项目整合开发状态: Phase I
项目研究机构: Research Triangle Institute (Originator),...
参考文献标题:A brain derived peptide preparation reduces the translation dependent loss of a cytoskeletal protein in primary cultured chicken neurons
文献作者:Wronski,R.; et al.
参考来源:J Neural Transm 2000,(59),263

Vapreotide acetate, BMY-41606, RC-160, Docrised, Sanvar, Octastatin

醋酸伐普肽伐普肽 Chemical Name: D-Phenylalanyl-cysteinyl-tyrosyl-D-tryptophyl-lysyl-valyl-cysteinyl-tryptophylamide cyclic (2-7)-disulfide acetate
CAS No. 116430-60-5, 103222-11-3 (free base)
项目整合开发状态:...
参考文献标题:Biologically active octapeptides
文献作者:Schally,A.V.; Cai,R.Z.
参考来源:US 4650787

Caspofungin acetate, MK-0991, MK-991, L-743872, Caspofungin MSD, Cancidas

醋酸卡泊芬净卡泊芬净 Chemical Name: (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanami...
参考文献标题:Aza cyclohexapeptide cpds.
文献作者:Balkovec,J.M.; Bouffard,F.A.; Black,R.M.(Merck & Co.,Inc.)
参考来源:CA 2118757; EP 0620232; JP 1994321986; US 5378804; WO 9421677

Bazedoxifene acetate, WAY-140424, TSE-424

醋酸巴多昔芬1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇Chemical Name: 2-(4-Hydroxyphenyl)-3-methyl-1-[4-[2-(perhydroazepin-1-yl)ethoxy]benzyl]-1H-indol-5-ol acetate
CAS No. 198481-33-3, 252555-...
参考文献标题:Estrogenic agents
文献作者:Miller,C.P.; Tran,B.D.; Collini,M.D.(American Home Products Corp.)
参考来源:EP 0802183; JP 1998036346; US 5998402

Flecainide acetate, E-0735, R-818, Apocard, Tambocor

醋酸氟卡胺氟卡尼 Chemical Name: N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate
CAS No. 54143-56-5, 54143-55-4 (free base)
项目整合开发状态: Launched-1982
项目研究机构: 3M Pharmaceutical...
参考文献标题:Process for the preparation of derivs.of pyrrolidine and piperidine
文献作者:Leir,C.M.(3M Pharmaceuticals)
参考来源:US 4642384

Nomegestrol acetate, TX-066, Uniplant, Lutenyl

醋酸诺美孕酮诺美孕酮 Chemical Name: 17alpha-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
CAS No. 58652-20-3, 58691-88-6 (free base)
项目整合开发状态: Launched-1985
项目研究机构: Th閞amex (Originator)
合成路线:E...
参考文献标题:3,20-Diketo-6-methyl-17alpha-hydroxy-19-norpregna-4,6-diene,its esters and the uses thereof
文献作者:Gastaud,J.M.
参考来源:GB 1515284; JP 7561456; US 4544555

Midecamycin acetate, Miokamycin, 1532-RB, MOM, Mosil, Miocamycin, Miocamen, Macroral

醋酸麦迪霉素麦迪霉素 Chemical Name: 9,3''-Di-O-acetylmidecamycin
CAS No. 55881-07-7, 35457-80-8 (free base)
项目整合开发状态: Launched-1985
项目研究机构: Meiji Seika (Originator), Bellon (Licensee), Menarini (Licen...
参考文献标题:9,3'',4''-Triacylester of the antibiotic SF-837 M1 substance and the production thereof
文献作者:Inouye,S.; Omoto,S.; Iwamatsu,K.; Tsuruoka,T.; Niida,T.; Kawasaki,T.(Meiji Seika Kaisha,Ltd.)
参考来源:BE 0832813; DE 2537375; FR 2282903; GB 1520145; JP 55012040B; US 4017607

Amantinium bromide

金刚溴铵Chemical Name: N-[2-(Adamant-1-ylcarbonyloxy)ethyl]-N,N-dimethyl-1-decanaminium bromide
CAS No. 58158-77-3
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound can be obtained as follo...
参考文献标题:
文献作者:Rovati,L.; Makovec,F.; Senin,P.
参考来源:BE 860980; DE 2752318; FR 2373514; GB 1574536; JP 65864; JP 8237582; US 4288609